• 中国精品科技期刊
  • 中国高校百佳科技期刊
  • 中国中文核心期刊
  • 中国科学引文数据库核心期刊
Advanced Search
HAN Han, ZHANG Yuanyuan, PAN Li, CHEN Zhengdong, XUE Lixuan, YU Boyang, KOU Junping. Advances of active ingredients of traditional Chinese medicine in the prevention and treatment of osteoarthritis[J]. Journal of China Pharmaceutical University, 2018, 49(3): 279-285. DOI: 10.11665/j.issn.1000-5048.20180304
Citation: HAN Han, ZHANG Yuanyuan, PAN Li, CHEN Zhengdong, XUE Lixuan, YU Boyang, KOU Junping. Advances of active ingredients of traditional Chinese medicine in the prevention and treatment of osteoarthritis[J]. Journal of China Pharmaceutical University, 2018, 49(3): 279-285. DOI: 10.11665/j.issn.1000-5048.20180304
shu

Advances of active ingredients of traditional Chinese medicine in the prevention and treatment of osteoarthritis

More Information
    Graphical Abstract
    • Abstract
  • Osteoarthritis(OA), a common chronic degenerative joint disease, rises gradually with age, which seriously affects the quality of life of middle-aged and elderly patients. Currently, the therapeutic medications such as nonsteroidal anti-inflammatory drugs(NSAIDs)and analgesics might improve OA symptoms, but cannot prevent the development of OA. The active ingredients of traditional Chinese medicine(TCM)have unique advantages in the treatment of OA. This article reviews the research progress of active ingredients of TCM in the prevention and treatment of OA reported by domestic and foreign journals in the past five years from the aspects of inhibition of the secretion of inflammation-related factors, improvement of cartilage matrix synthesis and catabolic imbalance, inhibition of chondrocyte apoptosis, promotion of chondrocyte proliferation, and regulation of estrogen levels, with an attempt to provide a theoretical basis for the development of new drugs for OA.
    • FullText(HTML)
    • References (50)
  • [1]
    Loeser RF,Goldring SR,Scanzello CR,et al.Osteoarthritis:a disease of the joint as an organ[J].Arthritis Rheum,2012,64(6):1697-1707.
    [2]
    Blagojevic M,Jinks C,Jeffery A,et al.Risk factors for onset of osteoarthritis of the knee in older adults:a systematic review and meta-analysis[J].Osteoarthritis Cartilage,2010, 18(1):24-33.
    [3]
    Mobasheri A.The future of osteoarthritis therapeutics:targeted pharmacological therapy[J].Curr Rheumatol Rep,2013,15(10):1-13.
    [4]
    Troeberg L,Nagase H.Proteases involved in cartilage matrix degradation in osteoarthritis[J].Biochim Biophys Acta,2012,1824(1):133-145.
    [5]
    Chen WP,Jin GJ,Xiong Y,et al.Rosmarinic acid down-regulates NO and PGE2 expression via MAPK pathway in rat chondrocytes[J].J Cell Mol Med,2017,22(1):346-353.
    [6]
    Wang SN,Xie GP,Qin CH,et al.Aucubin prevents interleukin-1 beta induced inflammation and cartilage matrix degradation via inhibition of NF-κB signaling pathway in rat articular chondrocytes[J].Int Immunopharmacol,2015,24(2):408-415.
    [7]
    Zheng W, Tao Z, Chen C, et al. Plumbagin prevents IL-1β-induced inflammatory response in human osteoarthritis chondrocytes and prevents the progression of osteoarthritis in mice[J].Inflammation,2017,40(3):849-860.
    [8]
    Chen YJ,Tsai KS,Chan DC,et al.Honokiol,a low molecular weight natural product,prevents inflammatory response and cartilage matrix degradation in human osteoarthritis chondrocytes[J].J Orthop Res,2014,32(4):573-580.
    [9]
    Cheng W,Jing J,Wang Z,et al.Chondroprotective effects of ginsenoside Rg1 in human osteoarthritis chondrocytes and a rat model of anterior cruciate ligament transection[J].Nutrients,2017,9(3):263.
    [10]
    Wang C, Zeng L, Zhang T, et al. Tenuigenin prevents IL-1β-induced inflammation in human osteoarthritis chondrocytes by suppressing PI3K/AKT/NF-κB signaling pathway[J].Inflammation,2016,39(2):807-812.
    [11]
    Zhao L,Ye J,Wu GT,et al.Gentiopicroside prevents interleukin-1 beta induced inflammation response in rat articular chondrocyte[J].J Ethnopharmacol,2015,172:100-107.
    [12]
    Chen WP, Xiong Y, Hu PF, et al. Baicalein inhibits MMPs expression via a MAPK-dependent mechanism in chondrocytes[J].Cell Physiol Biochem,2015,36(1):325-333.
    [13]
    Feng Z,Zheng W,Li X,et al.Cryptotanshinone protects against IL-1β-induced inflammation in human osteoarthritis chondrocytes and ameliorates the progression of osteoarthritis in mice[J].Int Immunopharmacol,2017,50:161-167.
    [14]
    Ma Z,Piao T,Wang Y,et al.Astragalin inhibits IL-1β-induced inflammatory mediators production in human osteoarthritis chondrocyte by inhibiting NF-κB and MAPK activation[J].Int Immunopharmacol,2015,25(1):83-87.
    [15]
    Liu L,Gu H,Liu H,et al.Protective effect of resveratrol against IL-1β-induced inflammatory response on human osteoarthritic chondrocytes partly via the TLR4/MyD88/NF-κB signaling pathway:an “in vitro study”[J].Int J Mol Sci,2014,15(4):6925-6940.
    [16]
    Leong DJ,Choudhury M,Hanstein R,et al.Green tea polyphenol treatment is chondroprotective,anti-inflammatory and palliative in a mouse posttraumatic osteoarthritis model[J].Arthritis Res Ther,2014,16(6):508.
    [17]
    Zeng L,Wang W,Rong XF,et al.Chondroprotective effects and multi-target mechanisms of Icariin in IL-1 beta-induced human SW 1353 chondrosarcoma cells and a rat osteoarthritis model[J].Int Immunopharmacol,2014,18(1):175-181.
    [18]
    Chien TY, Huang KH, Lee CJ, et al. Antinociceptive and anti-inflammatory effects of zerumbone against mono-iodoacetate-induced arthritis[J].Int J Mol Sci,2016,17(2):249.
    [19]
    Gao Y,Liu S,Huang J,et al.The ECM-cell interaction of cartilage extracellular matrix on chondrocytes[J].Biomed Res Int,2014,2014(2):648459.
    [20]
    Wu DQ,Zhong HM,Ding QH,et al.Protective effects of biochanin A on articular cartilage: in vitro and in vivo studies[J].BMC Complement Altern Med,2014,14(1):1-10.
    [21]
    Oh JS, Cho IA, Kang KR, et al. Biochanin-A antagonizes the interleukin-1β-induced catabolic inflammation through the modulation of NF-κB cellular signaling in primary rat chondrocytes[J].Biochem Biophys Res Commun,2016,477(4):723-730.
    [22]
    Chen WP,Hu ZN,Jin LB,et al.Licochalcone A inhibits MMPs and ADAMTSs via the NF-κB and Wnt/β-catenin signaling pathways in rat chondrocytes[J].Cell Physiol Biochem,2017,43(3):937-944.
    [23]
    Pan T,Wu D,Cai N,et al.Alpha-Mangostin protects rat articular chondrocytes against IL-1β-induced inflammation and slows the progression of osteoarthritis in a rat model[J].Int Immunopharmacol,2017,52:34-43.
    [24]
    Zhao H, Zhang T, Xia C, et al. Berberine ameliorates cartilage degeneration in interleukin-1β-stimulated rat chondrocytes and in a rat model of osteoarthritis via Akt signalling[J].J Cell Mol Med,2014,18(2):283-292.
    [25]
    Wang W, Zeng L, Wang ZM, et al. Ginsenoside Rb1 inhibits matrix metalloproteinase 13 through down-regulating Notch signaling pathway in osteoarthritis[J].Exp Biol Med,2015, 240(12):1614-1621.
    [26]
    Lee GJ,Cho IA,Kang KR,et al.Biological effects of the herbal plant-derived phytoestrogen bavachin in primary rat chondrocytes[J].Biol Pharm Bull,2015,38(8):1199-1207.
    [27]
    Wang F,Wu L,Li L,et al.Monotropein exerts protective effects against IL-1β-induced apoptosis and catabolic responses on osteoarthritis chondrocytes[J].Int Immunopharmacol,2014,23(2):575-580.
    [28]
    Du G, Song Y, Wei L, et al. Osthole inhibits proliferation and induces catabolism in rat chondrocytes and cartilage tissue[J].Cell Physiol Biochem,2015,36(6):2480-2493.
    [29]
    Zhang D,Huang B,Xiong C,et al.Pinocembrin inhibits matrix metalloproteinase expression in chondrocytes[J].IUBMB Life,2015,67(1):36-41.
    [30]
    Lepetsos P,Papavassiliou AG.ROS/oxidative stress signaling in osteoarthritis[J].Biochim Biophys Acta,2016,1862(4):576-591.
    [31]
    Khan NM,Haseeb A,Ansari MY,et al.Wogonin,a plant derived small molecule,exerts potent anti-inflammatory and chondroprotective effects through the activation of ROS/ERK/Nrf2 signaling pathways in human osteoarthritis chondrocytes[J].Free Radic Biol Med,2017,106:288-301.
    [32]
    Abusarah J,Benabdoun HA,Shi Q,et al.Elucidating the role of protandim and 6-gingerol in protection against osteoarthritis[J].J Cell Biochem,2017,118(5):1003-1013.
    [33]
    Li XR,Li J,Ren Q,et al.The molecular mechanism of treating osteoarthritis with dipsacus saponins by inhibiting chondrocyte apoptosis[J].Exp Ther Med,2017,14(5):4527-4532.
    [34]
    Zhang XH,Xu XX,Xu T.Ginsenoside Ro suppresses interleukin-1β-induced apoptosis and inflammation in rat chondrocytes by inhibiting NF-κB[J].Chin J Nat Med(中国天然药物),2015,13(4):283-289.
    [35]
    Huang Y,Wu D,Fan W.Protection of ginsenoside Rg1 on chondrocyte from IL-1β-induced mitochondria-activated apoptosis through PI3K/Akt signaling[J].Mol Cell Biochem,2014,392(1/2):249-257.
    [36]
    Liang Q,Wang XP,Chen TS.Resveratrol protects rabbit articular chondrocyte against sodium nitroprusside-induced apoptosis via scavenging ROS[J].Apoptosis,2014,19(9):1354-1363.
    [37]
    Jin H,Liang Q,Chen T,et al.Resveratrol protects chondrocytes from apoptosis via altering the ultrastructural and biomechanical properties:an AFM study[J].PLoS One,2014,9(3):e91611.
    [38]
    Liu S,Yang H,Hu B,et al.Sirt1 regulates apoptosis and extracellular matrix degradation in resveratrol-treated osteoarthritis chondrocytes via the Wnt/β-catenin signaling pathways[J].Exp Ther Med,2017,14(5):5057-5062.
    [39]
    Zhou Y, Liu SQ, Yu L, et al. Berberine prevents nitric oxide-induced rat chondrocyte apoptosis and cartilage degeneration in a rat osteoarthritis model via AMPK and p38 MAPK signaling[J].Apoptosis,2015,20(9):1187-1199.
    [40]
    Pan Y,Chen D,Lu Q,et al.Baicalin prevents the apoptosis of endplate chondrocytes by inhibiting the oxidative stress induced by H2O2[J].Mol Med Rep,2017,16(3):2985-2991.
    [41]
    Young IC,Chuang ST,Hsu CH,et al.Protective effects of aucubin on osteoarthritic chondrocyte model induced by hydrogen peroxide and mechanical stimulus[J].BMC Complement Altern Med,2017,17(1):91.
    [42]
    Na JY,Song K,Kim S,et al.Rutin protects rat articular chondrocytes against oxidative stress induced by hydrogen peroxide through SIRT1 activation[J].Biochem Biophys Res Commun,2016,473(4):1301-1308.
    [43]
    Zhuang C,Xu NW,Gao GM,et al.Polysaccharide from angelica sinensis protects chondrocytes from H2O2-induced apoptosis through its antioxidant effects in vitro[J].Int J Biol Macromol,2016,87:322-328.
    [44]
    Weng X,Lin P,Liu F,et al.Achyranthes bidentata polysaccharides activate the Wnt/β-catenin signaling pathway to promote chondrocyte proliferation[J].Int J Mol Med,2014,34(4):1045-1050.
    [45]
    Fu C,Zheng C,Lin J,et al.Cibotium barometz polysaccharides stimulate chondrocyte proliferation in vitro by promoting G1/S cell cycle transition[J].Mol Med Rep,2017,15(5):3027-3034.
    [46]
    Luo L,Wei Q,Liu L,et al.Protocatechuic acid benefits proliferation and phenotypic maintenance of rabbit articular chondrocytes:an in vitro study[J].Exp Ther Med,2015,9(5):1865-1870.
    [47]
    Xu K,Pan X,Sun Y,et al.Psoralen activates cartilaginous cellular functions of rat chondrocytes in vitro[J].Pharm Biol,2015,53(7):1010-1015.
    [48]
    Zheng W,Lin P,Ma Y,et al.Psoralen promotes the expression of cyclin D1 in chondrocytes via the Wnt/β-catenin signaling pathway[J].Int J Mol Med,2017,40(5):1377-1384.
    [49]
    Zhang X,Xu X,Xu T,et al.β-Ecdysterone suppresses interleukin-1β-induced apoptosis and inflammation in rat chondrocytes via inhibition of NF-κB signaling pathway[J].Drug Dev Res,2014,75(3):195-201.
    [50]
    You JS,Cho IA,Kang KR,et al.Coumestrol counteracts interleukin-1β-induced catabolic effects by suppressing inflammation in primary rat chondrocytes[J].Inflammation,2017, 40(1):79-91.
    • Related Articles

  • Related Articles

    [1]LI Xue, AI Yongling, HE Qunye, YANG Gongjun, WANG Jing. Detection of prostate specific antigen-based on dual signal amplified electrochemical immunoassay[J]. Journal of China Pharmaceutical University, 2018, 49(4): 433-440. DOI: 10.11665/j.issn.1000-5048.20180408
    [2]SONG Fengjuan, AI Yongling, ZHONG Wenying, WANG Jing. Detection of copper ions and glutathione based on off-on fluorescent graphene quantum dots[J]. Journal of China Pharmaceutical University, 2018, 49(1): 87-92. DOI: 10.11665/j.issn.1000-5048.20180112
    [3]ZHOU Weisai, WU Zimei, BAGULEY Bruce C., LI Caibin, ZHANG Wenli, LIU Jianping. Preparation of CI-921 mixed micelles and determination of its entrapment efficiency by method of dialysis and fitting[J]. Journal of China Pharmaceutical University, 2016, 47(5): 575-580. DOI: 10.11665/j.issn.1000-5048.20160512
    [4]WU Mingming, FANG Lei, GOU Shaohua, CHEN Li. 以2-甲基-2-取代苯氧基丙酸为离去基团的铂(Ⅱ)配合物的合成、表征及细胞毒活性[J]. Journal of China Pharmaceutical University, 2013, 44(4): 303-306. DOI: 10.11665/j.issn.1000-5048.20130403
    [5]Synthesis of violet-near-infrared-emitting quantum dots using N-acetyl-L-cysteine as ligand[J]. Journal of China Pharmaceutical University, 2010, 41(5): 456-461.
    [6]BESN System of Multi-channel Tail-artery Blood Pressure Measurement[J]. Journal of China Pharmaceutical University, 2004, (5): 80-83.
    [7]Preparation and Antibacterial Testing of dihydroxyaluminum sodium carbonate and its Tablet[J]. Journal of China Pharmaceutical University, 1998, (3): 84-86.
    [8]DISCUSSION OF STABILITY OF THE YIN-YANG EQUATION[J]. Journal of China Pharmaceutical University, 1987, (1): 40-44.
    [9]UV SPECTROPHOTOMETRIC ANALYSIS OF MULTICOMPONENT COMPLEX PREPARATION BY THE LEAST SQUARES AREA FITTING METHOD[J]. Journal of China Pharmaceutical University, 1986, (3): 201-207.
    [10]Dong Shanshi, Yang Jingrong, An Dengkui. DETERMINATION OF NONOXYNOL-9 IN THE CAPSHAPED CONTRACEPTIVE FILMS BY ORTHOGONAL POLYNOMIAL SPECTROPHOTOMETRY[J]. Journal of China Pharmaceutical University, 1982, (3): 57-58.

Catalog

    Get Citation
    PDF
    XML
    Article views (894) PDF downloads (2098) Cited by()
    Turn off MathJax
    Article Contents
    Abstract
    References
    Related Articles

    Copyright © Journal of China Pharmaceutical University苏ICP备12050101号-2

    Address：24 Tongjia Lane, Nanjing City, Jiangsu Province （210009）Tel: 025-83271566E-mail: xuebao@cpu.edu.cn

    Supported by: Beijing Renhe Information Technology Co., Ltd.  Baidu Analytics

    Total visits：292734

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return