Recent progress in autophagy and vascular calcification

YANG Rui; ZHU Yi; WANG Yin; MA Wenqi; WANG Xin; HAN Xiqiong; LIU Naifeng

doi:10.11665/j.issn.1000-5048.20180403

Journal of China Pharmaceutical University > 2018 > 49(4): 401-406. > DOI: 10.11665/j.issn.1000-5048.20180403

YANG Rui, ZHU Yi, WANG Yin, MA Wenqi, WANG Xin, HAN Xiqiong, LIU Naifeng. Recent progress in autophagy and vascular calcification[J]. Journal of China Pharmaceutical University, 2018, 49(4): 401-406. DOI: 10.11665/j.issn.1000-5048.20180403

Citation:

PDF (1688 KB)

Recent progress in autophagy and vascular calcification

More Information

Graphical Abstract

Abstract

Abstract

Autophagy is a “self-devouring” biological process of the degradation of organelles and proteins by lysosomes in eukaryotic cells. In the past few years, some results revealed that autophagy played an important role in the regulation of vascular calcification. This review summarized the recent studies on autophagy in the process of vascular calcification, and discussed the effects of electrolyte imbalance, matrix vesicle release, oxidative stress, inflammatory reaction of vascular endothelial cells, and lipid metabolism in autophagy. The research progress of β-catenin/AMPK/CREB/Nrf2-ARE/Erα signal transduction pathways in autophagy induction was reviewed.
- autophagy,
- vascular calcification,
- mechanism,
- signal transduction pathway

FullText(HTML)

References (41)

References

[1]	Nakatogawa H,Suzuki K,Kamada Y,et al.Dynamics and diversity in autophagy mechanisms:lessons from yeast[J].Nat Rev Mol Cell Biol,2009,10(7):458-467.
[2]	Klionsky DJ. Autophagy: from phenomenology to molecular understanding in less than a decade[J].Nat Rev Mol Cell Biol,2007,8(11):931-937.
[3]	Levine B,Klionsky DJ.Development by self-digestion:molecular mechanisms and biological functions of autophagy[J].Dev Cell,2004,6(4):463-477.
[4]	Kourtis N, Tavernarakis N. Autophagy and cell death in model organisms[J].Cell Death Differ,2009,16(1):21-30.
[5]	Shintani T, Klionsky DJ. Autophagy in health and disease: a double-edged sword[J].Science,2004,306(5698):990-995.
[6]	Harding TM,Hefnergravink A,Thumm M,et al.Genetic and phenotypic overlap between autophagy and the cytoplasm to vacuole protein targeting pathway[J].J Biol Chem,1996,271(30):17621-17624.
[7]	Klionsky DJ,Cregg JM,Jr WAD,et al.A unified nomenclature for yeast autophagy-related genes[J].Dev Cell,2003,5(4):539-545.
[8]	Mizushima N,Yoshimori T,Ohsumi Y,The role of Atg proteins in autophagosome formation[J].Annu Rev Cell Dev Biol,2011,27(1):107-132.
[9]	Ravikumar B,Moreau K,Jahreiss L,et al.Plasma membrane contributes to the formation of pre-autophagosomal structures[J].Nat Cell Biol,2010,12(8):747-757.
[10]	Tanida I,Ueno T,Kominami E.LC3 and autophagy[J].Methods Mol Biol,2008,445:77-88.
[11]	Cadwell K.Crosstalk between autophagy and inflammatory signalling pathways:balancing defence and homeostasis[J].Nat Rev Immunol,2016,16(11):661-675.
[12]	Valdivielso JM.Vascular calcification:types and mechanisms[J].Nefrologia,2011,31(2):142-147.
[13]	Huang H.Basic and translational research of vascular calcification[J].J Sun Yat-Sen Univ Med Sci(中山大学学报医学科学版),2017,38(2):184-188.
[14]	Dai XY,Zhao MM,Cai Y,et al.Phosphate-induced autophagy counteracts vascular calcification by reducing matrix vesicle release[J].Kidney Int,2013,83(6):1042-1051.
[15]	Ciceri P,Elli F,Cappelletti L,et al.A new in vitro model to delay high phosphate-induced vascular calcification progression[J].Mol Cell Biochem,2015,410(1/2):197-206.
[16]	Ciceri P,Elli F,Braidotti P,et al.Iron citrate reduces high phosphate-induced vascular calcification by inhibiting apoptosis[J].Atherosclerosis,2016,254:93-101.
[17]	Chen NX,O′Neill KD,Chen X,et al.Annexin-mediated matrix vesicle calcification in vascular smooth muscle cells[J].J Bone Miner Res,2008,23(11):1798-1805.
[18]	Proudfoot D, Skepper JN, Hegyi L, et al. Apoptosis regulates human vascular calcification in vitro evidence for initiation of vascular calcification by apoptotic bodies[J].Circ Res,2000,87(11):1055-1062.
[19]	Mistiaen W, Knaapen M. Evaluation of cell death markers in severe calcified aortic valves[J].Methods Enzymol,2009,453:365-378.
[20]	Somers P,Knaapen M,Kockx M,et al.Histological evaluation of autophagic cell death in calcified aortic valve stenosis[J].J Heart Valve Dis,2006,15(1):43-48.
[21]	Chang HB,Javed A,Dai Q,et al.Oxidative stress induces vascular calcification through modulation of the osteogenic transcription factor Runx2 by AKT signaling[J].J Biol Chem,2008,283(22):15319-15327.
[22]	Montezano AC, Touyz RM. Touyz molecular mechanisms of hypertension—reactive oxygen species and antioxidants:a basic science update for the clinician[J].Can J Cardiol,2012,28(3):288-295.
[23]	Sudo R,Sato F,Azechi T,et al.7-Ketocholesterol-induced lysosomal dysfunction exacerbates vascular smooth muscle cell calcification via oxidative stress[J].Genes Cells,2015,20(12):982-991.
[24]	Aikawa E,Nahrendorf M,Figueiredo JL,et al.Osteogenesis associates with inflammation in early-stage atherosclerosis evaluated by molecular imaging in vivo[J].Circulation,2007,116(24):2841-2850.
[25]	Bessueille L,Magne D.Inflammation:a culprit for vascular calcification in atherosclerosis and diabetes[J].Cell Mol Life Sci,2015,72(13):2475-2489.
[26]	Marinelli A, Orlandi L, Stivali G. C-reactive protein levels are associated with arterial media calcification in nondiabetic patients with end-stage renal disease on long-term hemodialysis[J].Clin Nephrol,2011,76(6):425-434.
[27]	Pankratz F,Hohnloser C,Bemtgen X,et al.MicroRNA-100 suppresses chronic vascular inflammation by stimulation of endothelial autophagy[J].Circ Res,2018,122(3):417-432.
[28]	Yang D,Xiao C,Long F,et al.HDAC4 regulates vascular inflammation via activation of autophagy[J].Cardiovasc Res,2018,114(7):1016-1028.
[29]	Parhami F,Basseri B,Hwang J,et al.High-density lipoprotein regulates calcification of vascular cells[J].Circ Res,2002,91(7):570-576.
[30]	He Z,Liu H,Agostini M,et al.p73 regulates autophagy and hepatocellular lipid metabolism through a transcriptional activation of the ATG5 gene[J].Cell Death Differ,2013,20(10):1415-1424.
[31]	Ouimet M,Franklin V,Mak E,et al.Autophagy regulates cholesterol efflux from macrophage foam cells via lysosomal acid lipase[J].Cell Metab,2011,13(6):655-667.
[32]	Qiao L,Zhang X,Liu M,et al.Ginsenoside Rb1 enhances atherosclerotic plaque stability by improving autophagy and lipid metabolism in macrophage foam cells[J].Front Pharmacol,2017,8:727.
[33]	Liao L,Zhuang X,Li W,et al.Polysaccharide from Fuzi protects against OxLDLinduced calcification of human vascular smooth muscle cells by increasing autophagic activity[J].Mol Med Rep,2018,17(4):5109-5115.
[34]	Wang X,Zhang PH.Advances in research on the modulation of autophagy by Ras/Raf/M EK/ERK signaling pathway[J].J China Pharm Univ(中国药科大学学报),2017,48(1):110-116.
[35]	Liu YH,Kong W.The mechanisms of medial vascular calcification[J].Acta physiol Sin(生理学报),2016(5):592-610.
[36]	Liu D,Cui W,Liu B,et al.Atorvastatin protects vascular smooth muscle cells from TGF-beta1-stimulated calcification by inducing autophagy via suppression of the beta-catenin pathway[J].Cell Physiol Biochem,2014,33(1):129-141.
[37]	Xu M,Liu L,Song C,et al.Ghrelin improves vascular autophagy in rats with vascular calcification[J].Life Sci,2017,179:23-29.
[38]	Sun Y,Byon CH,Yang Y,et al.Dietary potassium regulates vascular calcification and arterial stiffness[J].JCI Insight,2017,2(19).doi: 10.1172/jci.insight.94920.
[39]	Ha CM, Park S, Choi YK, et al. Activation of Nrf2 by dimethyl fumarate improves vascular calcification[J].Vascul Pharmacol,2014,63(1):29-36.
[40]	Yao L,Wang J,Tian BY,et al.Activation of the Nrf2-ARE signaling pathway prevents hyperphosphatemia-induced vascular calcification by inducing autophagy in renal vascular smooth muscle cells[J].J Cell Biochem,2017,118(12):4708-4715.
[41]	Peng YQ,Xiong D,Lin X,et al.Oestrogen inhibits arterial calcification by promoting autophagy[J].Sci Rep,2017,7(1):3549.

Cited By

Get Citation

PDF

XML

Article views (1441) PDF downloads (1831)

Turn off MathJax

Article Contents

Abstract

References

Recent progress in autophagy and vascular calcification

Abstract

References

Catalog

Export File

Citation

Format

Content