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CHEN Haitao, LU Xiaofei, HAN Fujiao, WANG Wenxin, FU Jingguo, CHEN Hui. Asymmetric hydrogenation of methyl-2-acylamino-3-arylacrylate[J]. Journal of China Pharmaceutical University, 2018, 49(5): 553-557. DOI: 10.11665/j.issn.1000-5048.20180506
Citation: CHEN Haitao, LU Xiaofei, HAN Fujiao, WANG Wenxin, FU Jingguo, CHEN Hui. Asymmetric hydrogenation of methyl-2-acylamino-3-arylacrylate[J]. Journal of China Pharmaceutical University, 2018, 49(5): 553-557. DOI: 10.11665/j.issn.1000-5048.20180506

Asymmetric hydrogenation of methyl-2-acylamino-3-arylacrylate

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  • By using(S)-MonoPHOS and [Rh(COD)2]BF4 as catalyst, the asymmetric hydrogenation reactions of methyl-2-acylamino-3-arylacrylate and the effect of different amino protective groups on hydrogenation efficacy were studied. The products resulting from asymmetric hydrogenation were hydrolyzed by hydrochloric acid, and the corresponding amino acids were obtained at yields of 63%- 92%.
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