Chemical constituents extracted from<i> Dictamnus dasycarpus</i> and their <i>α</i>-glucosidase inhibitory activity

YANG Xiaojun; AI Fengfeng; LIN Junbing; TANG Jiangjiang

doi:10.11665/j.issn.1000-5048.20190105

Journal of China Pharmaceutical University > 2019 > 50(1): 41-45. > DOI: 10.11665/j.issn.1000-5048.20190105

YANG Xiaojun, AI Fengfeng, LIN Junbing, TANG Jiangjiang. Chemical constituents extracted from Dictamnus dasycarpus and their α-glucosidase inhibitory activity[J]. Journal of China Pharmaceutical University, 2019, 50(1): 41-45. DOI: 10.11665/j.issn.1000-5048.20190105

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Chemical constituents extracted from Dictamnus dasycarpus and their α-glucosidase inhibitory activity

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Five compounds were isolated from the petroleum ether extract of Dictamnus dasycarpus using various chromatographic techniques, such as column chromatography over silica gel and Sephadex LH-20. Their structures were elucidated by spectroscopic data(IR, MS, NMR), which were identified as docosanol( 1 ), ethyl 2, 2-dibenzhydryl-3, 3-di-phenylpropionate( 2 ), limonin( 3 ), obacunone( 4 )and dictamnine( 5 ). Compound 2 was a new compound and compound 1 was isolated from this plant for the first time. PNPG method was used to determine α-glucosidase inhibitory activity of these compounds. The results indicated that compounds 3 - 5 possessed stronger inhibitory activities than the positive control of acarbose, which provided a theoretical basis for further development and utilization of Dictamnus dasycarpus.
- Dictamnus dasycarpus,
- chemical constituents,
- α-glucosidase,
- inhibitory activity,
- diabetes

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