Role of non-coding RNA in pulmonary arterial hypertension

Non-coding RNA(ncRNA), a group of RNAs including microRNA, lncRNA, ceRNA, etc. , has multiple functions without protein-coding. It can regulate gene expression through epigenetics by various aspects such as transcription and post-transcription regulation. Recently, a large number of studies have found that ncRNA can cause a variety of diseases, such as cardiovascular disease, cancer, pulmonary arterial hypertension(PAH)and so on. This paper reviews the research progress on the role of ncRNA in PAH formation to provide theoretical foundation for the treatment of PAH.