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XU Yi, YU Feng, LIU Yun. Role of non-coding RNA in pulmonary arterial hypertension[J]. Journal of China Pharmaceutical University, 2019, 50(1): 107-112. DOI: 10.11665/j.issn.1000-5048.20190115
Citation: XU Yi, YU Feng, LIU Yun. Role of non-coding RNA in pulmonary arterial hypertension[J]. Journal of China Pharmaceutical University, 2019, 50(1): 107-112. DOI: 10.11665/j.issn.1000-5048.20190115
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Role of non-coding RNA in pulmonary arterial hypertension

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    • Abstract
  • Non-coding RNA(ncRNA), a group of RNAs including microRNA, lncRNA, ceRNA, etc. , has multiple functions without protein-coding. It can regulate gene expression through epigenetics by various aspects such as transcription and post-transcription regulation. Recently, a large number of studies have found that ncRNA can cause a variety of diseases, such as cardiovascular disease, cancer, pulmonary arterial hypertension(PAH)and so on. This paper reviews the research progress on the role of ncRNA in PAH formation to provide theoretical foundation for the treatment of PAH.
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  • [1]
    Zhu N,Welch CL,Wang J,et al.Rare variants in SOX17 are associated with pulmonary arterial hypertension with congenital heart disease[J].Genome Med,2018,10(1):56.
    [2]
    Berger RM,Beghetti M,Humpl T,et al.Clinical features of paediatric pulmonary hypertension:a registry study[J].Lancet,2012,379(9815):537-546.
    [3]
    Palazzini M,Dardi F,Manes A,et al.Pulmonary hypertension due to left heart disease:analysis of survival according to the haemodynamic classification of the 2015 ESC/ERS guidelines and insights for future changes[J].Eur J Heart Fail,2018,20(2):248-255.
    [4]
    Kim Y,Kim VN.MicroRNA factory:RISC assembly from precursor microRNAs[J].Mol cell,2012,46(4):384-386.
    [5]
    Quinn JJ,Chang HY.Unique features of long non-coding RNA biogenesis and function[J].Nat Rev Genet,2016,17(1):47-62.
    [6]
    Guttman M,Rinn JL.Modular regulatory principles of large non-coding RNAs[J].Nature,2012,482(7385):339-346.
    [7]
    Cech TR,Steitz JA.The noncoding RNA revolution-trashing old rules to forge new ones[J].Cell,2014,157(1):77-94.
    [8]
    Schuergers N,Mullineaux CW,Wilde A.Cyanobacteria in motion[J].Curr Opin Plant Biol,2017,37:109-115.
    [9]
    Kiss T.Small nucleolar RNAs:an abundant group of noncoding RNAs with diverse cellular functions[J].Cell,2002,109(2):145-148.
    [10]
    Lagos-Quintana M,Rauhut R,Lendeckel W,et al.Identification of novel genes coding for small expressed RNAs[J].Science,2001,294(5543):853-858.
    [11]
    Flynt AS,Lai EC.Biological principles of microRNA-mediated regulation:shared themes amid diversity[J].Nat Rev Genet,2008,9(11):831-842.
    [12]
    Huang B,Li H,Huang L,et al.Clinical significance of microRNA 138 and cyclin D3 in hepatocellular carcinoma[J].J Surg Res,2015,193(2):718-723.
    [13]
    Gou D,Ramchandran R,Peng X,et al.miR-210 has an antiapoptotic effect in pulmonary artery smooth muscle cells during hypoxia[J].Am J Physiol Lung Cell Mol Physiol,2012,303(8):L682-691.
    [14]
    De la Garza MM,Cumpian AM,Daliri S,et al.COPD-Type lung inflammation promotes K-ras mutant lung cancer through epithelial HIF-1alpha mediated tumor angiogenesis and proliferation[J].Oncotarget,2018,9(68):32972-32983.
    [15]
    Liu JJ,Zhang H,Xing F,et al.MicroRNA138 promotes proliferation and suppresses mitochondrial depolarization in human pulmonary artery smooth muscle cells through targeting TASK1[J].Mol Med Rep,2018,17(2):3021-3027.
    [16]
    Yue J, Guan J, Wang X, et al. MicroRNA-206 is involved in hypoxia-induced pulmonary hypertension through targeting of the HIF-1alpha/Fhl-1 pathway[J].Lab Invest,2013,93(7):748-759.
    [17]
    Guo L,Qiu Z,Wei L,et al.The microRNA-328 regulates hypoxic pulmonary hypertension by targeting at insulin growth factor 1 receptor and L-type calcium channel-alpha1C[J].Hypertension,2012,59(5):1006-1013.
    [18]
    Sawada H,Saito T,Nickel NP,et al.Reduced BMPR2 expression induces GM-CSF translation and macrophage recruitment in humans and mice to exacerbate pulmonary hypertension[J].J Exp Med,2014,211(2):263-280.
    [19]
    Abbasi Y,Jabbari J,Jabbari R,et al.Exome data clouds the pathogenicity of genetic variants in pulmonary arterial hypertension[J].Mol Genet Genomic Med,2018,6(5):835-844.
    [20]
    Pickworth J,Rothman A,Iremonger J,et al.Differential IL-1 signaling induced by BMPR2 deficiency drives pulmonary vascular remodeling[J].Pulm Circ,2017,7(4):768-776.
    [21]
    Brock M,Trenkmann M,Gay RE,et al.Interleukin-6 modulates the expression of the bone morphogenic protein receptor type II through a novel STAT3-microRNA cluster 17/92 pathway[J].Circ Res,2009,104(10):1184-1191.
    [22]
    Sosa Iglesias V,Giuranno L,Dubois LJ,et al.Drug resistance in non-small cell lung cancer:a potential for NOTCH targeting[J].Front Oncol,2018,8:267.
    [23]
    Li X,Zhang X,Leathers R,et al.Notch3 signaling promotes the development of pulmonary arterial hypertension[J].Nat Med,2009,15(11):1289-1297.
    [24]
    Wang D,Zhang H,Li M,et al.MicroRNA-124 controls the proliferative,migratory,and inflammatory phenotype of pulmonary vascular fibroblasts[J].Circ Res,2014,114(1):67-78.
    [25]
    Sessa R,Hata A.Role of microRNAs in lung development and pulmonary diseases[J].Pulm Circ,2013,3(2):315-328.
    [26]
    Yu H,Xu M,Dong Y,et al.1,25(OH)2D3 attenuates pulmonary arterial hypertension via microRNA-204 mediated Tgfbr2/Smad signaling[J].Exp Cell Res,2018,362(2):311-323.
    [27]
    Wang FE,Zhang C,Maminishkis A,et al.MicroRNA-204/211 alters epithelial physiology[J].FASEB J,2010,24(5):1552-1571.
    [28]
    Zhang Y,Zhang R,Luo G,et al.Long noncoding RNA SNHG1 promotes cell proliferation through PI3K/AKT signaling pathway in pancreatic ductal adenocarcinoma[J].J Cancer,2018,9(15):2713-2722.
    [29]
    Khorkova O,Hsiao J,Wahlestedt C.Basic biology and therapeutic implications of lncRNA[J].Adv Drug Deliv Rev,2015,87:15-24.
    [30]
    Johnsson P,Lipovich L,Grander D,et al.Evolutionary conservation of long non-coding RNAs,sequence,structure,function[J].Biochim Biophys Acta,2014,1840(3):1063-1071.
    [31]
    Deng L,Bradshaw AC,Baker AH.Role of noncoding RNA in vascular remodelling[J].Curr Opin Lipidol,2016,27(5):439-448.
    [32]
    Zhang L,Wang Q,Wang F,et al.LncRNA LINC01446 promotes glioblastoma progression by modulating miR-489-3p/TPT1 axis[J].Biochem Biophys Res Commun,2018,503(3):1484-1490.
    [33]
    Zhuo Y, Zeng Q, Zhang P, et al. Functional polymorphism of lncRNA MALAT1 contributes to pulmonary arterial hypertension susceptibility in Chinese people[J].Clin Chem Lab Med,2017,55(1):38-46.
    [34]
    Michalik KM,You X,Manavski Y,et al.Long noncoding RNA MALAT1 regulates endothelial cell function and vessel growth[J].Circ Res,2014,114(9):1389-1397.
    [35]
    Zhu B,Gong Y,Yan G,et al.Down-regulation of lncRNA MEG3 promotes hypoxia-induced human pulmonary artery smooth muscle cell proliferation and migration via repressing PTEN by sponging miR-21[J].Biochem Biophys Res Commun,2018,495(3):2125-2132.
    [36]
    Leisegang MS,Fork C,Josipovic I,et al.Long noncoding RNA MANTIS facilitates endothelial angiogenic function[J].Circulation,2017,136(1):65-79.
    [37]
    Wang J,Zhu MC,Kalionis B,et al.Characteristics of circular RNA expression in lung tissues from mice with hypoxiainduced pulmonary hypertension[J].Int J Mol Med,2018,42(3):1353-1366.
    [38]
    Legnini I,Di Timoteo G,Rossi F,et al.Circ-ZNF609 is a circular rna that can be translated and functions in myogenesis[J].Mol Cell,2017,66(1):22-37.
    [39]
    Shan K,Liu C,Liu BH,et al.Circular noncoding RNA HIPK3 mediates retinal vascular dysfunction in diabetes mellitus[J].Circulation,2017,136(17):1629-1642.
    [40]
    Saintigny P,Mitani Y,Pytynia KB,et al.Frequent PTEN loss and differential HER2/PI3K signaling pathway alterations in salivary duct carcinoma:implications for targeted therapy[J].Cancer,2018,124(18):3693-3705.
    [41]
    Ding Q,Chen Y,Dong S,et al.Astrocyte elevated gene-1 is overexpressed in non-small-cell lung cancer and associated with increased tumour angiogenesis[J].Interact Cardiovasc Thorac Surg,2018,26(3):395-401.
    [42]
    Wang K,Long B,Liu F,et al.A circular RNA protects the heart from pathological hypertrophy and heart failure by targeting miR-223[J].Eur Heart J,2016,37(33):2602-2611.
    [43]
    Wu Y, Tang TT, Zhu QH, et al. Mechanisms of miR-29a in migration and invasion of breast cancer MCF-7 cells in vitro[J].J China Pharm Univ(中国药科大学学报),2018,49(3):348-353.
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