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WANG Xue, YANG Tingting, JIANG Zhenzhou, ZHANG Luyong. Tight junctions-associated proteins:a novel therapeutic target for cholestatic liver injury[J]. Journal of China Pharmaceutical University, 2019, 50(2): 143-151. DOI: 10.11665/j.issn.1000-5048.20190203
Citation: WANG Xue, YANG Tingting, JIANG Zhenzhou, ZHANG Luyong. Tight junctions-associated proteins:a novel therapeutic target for cholestatic liver injury[J]. Journal of China Pharmaceutical University, 2019, 50(2): 143-151. DOI: 10.11665/j.issn.1000-5048.20190203
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Tight junctions-associated proteins:a novel therapeutic target for cholestatic liver injury

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    • Abstract
  • The occurrence of cholestatic liver injury is accompanied by the alterations of hepatocyte polarization and bile acid homeostasis. Located in epithelial cells, tight junctions(TJs)are a special barrier structure which are important in maintaining permeability and bile acid homeostasis. Based on the fully analysis and discussion of TJs, the latest therapeutic drugs for cholestasis were summaried, which may provide new perspectives and potential therapeutic agents for the treatment of cholestatic liver injury.
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