Surface solid dispersion of honokiol-croscarmellose sodium:preparation and characterization

DONG Wujun; FU Qiang; LYU Huixia

doi:10.11665/j.issn.1000-5048.20190406

Journal of China Pharmaceutical University > 2019 > 50(4): 417-422. > DOI: 10.11665/j.issn.1000-5048.20190406

DONG Wujun, FU Qiang, LYU Huixia. Surface solid dispersion of honokiol-croscarmellose sodium:preparation and characterization[J]. Journal of China Pharmaceutical University, 2019, 50(4): 417-422. DOI: 10.11665/j.issn.1000-5048.20190406

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Surface solid dispersion of honokiol-croscarmellose sodium:preparation and characterization

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Abstract

The surface solid dispersion of honokiol was prepared by melting method with croscarmellose sodium as carrier to improve the dissolution rate of honokiol, taking the advantage of its low melting point. The dissolution rate and stability test of surface solid dispersion of honokiol were carried out. Its physical properties were then investigated by DSC, PXRD and SEM analysis. The results indicated that the dissolution rate of honokiol from sodium solid dispersion was more than 90% at 15 min while its mean dissolution time was significantly decreased. Honokiol was distributed on the surface of croscarmellose sodium in the form of microcrystal; moreover, its dissolution behavior didn′t change significantly after six months of stability tests. Therefore, surface solid dispersion of honokionl could be prepared by simple process. The formed solid dispersion achieved high drug loading and fast in vitro dissolution rate, which could provide a novel idea for developing solid preparations of honokiol.
- honokiol,
- croscarmellose sodium,
- surface solid dispersion,
- dissolution,
- melting method

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