Preparation, <i>in vitro </i>imaging and antitumor activity of the second near-infrared imaging drug-loaded liposomes

WANG Zian; LIU Yang; WANG Peng; JIANG Yifei; JI Min

doi:10.11665/j.issn.1000-5048.20190408

Journal of China Pharmaceutical University > 2019 > 50(4): 438-443. > DOI: 10.11665/j.issn.1000-5048.20190408

WANG Zian, LIU Yang, WANG Peng, JIANG Yifei, JI Min. Preparation, in vitro imaging and antitumor activity of the second near-infrared imaging drug-loaded liposomes[J]. Journal of China Pharmaceutical University, 2019, 50(4): 438-443. DOI: 10.11665/j.issn.1000-5048.20190408

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Preparation, in vitro imaging and antitumor activity of the second near-infrared imaging drug-loaded liposomes

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The combination of diagnosis and treatment through nanotechnology is conducive to the development of cancer treatment. Fluorescent imaging in the second near-infrared window(NIR-II)developed rapidly in recent years due to its imaging advantages. In this paper, we prepared a novel nano drug system, DOX-IR1061-cationic liposome, in which NIR-II fluorescent probe IR1061 was loaded as imaging agents and doxorubicin was loaded as therapeutic agents. It also explores enhanced cellular uptake and cancer cell inhibition rate through octadecylamine. Our NIR-II performance test on liposomes showed that DOX-IR1061-cationic liposome has NIR-II imaging ability. Analysis of liposome cell uptake behavior and cancer cell inhibition experiments demonstrated that octadecylamine can promote liposome uptake by cells and synergize with DOX to enhance anticancer effects. This suggests that the DOX-IR1061-cationic liposome can be used to achieve imaging and therapy effect with further research value.
- NIR-II imaging,
- doxorubicin,
- theranostics,
- cationic liposome,
- antitumor activity

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Preparation, in vitro imaging and antitumor activity of the second near-infrared imaging drug-loaded liposomes

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