Chemical constituents of<i> Uvaria grandiflora</i>

ZHU Qian; HUANG Qilong; ZHANG Chunlei; CAO Zhengyu

doi:10.11665/j.issn.1000-5048.20190605

Journal of China Pharmaceutical University > 2019 > 50(6): 666-671. > DOI: 10.11665/j.issn.1000-5048.20190605

ZHU Qian, HUANG Qilong, ZHANG Chunlei, CAO Zhengyu. Chemical constituents of Uvaria grandiflora[J]. Journal of China Pharmaceutical University, 2019, 50(6): 666-671. DOI: 10.11665/j.issn.1000-5048.20190605

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Chemical constituents of Uvaria grandiflora

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Chemical investigation of the roots of Uvaria grandiflora by repeated column chromatography(CC)over silica gel, ODS, Sephadex LH-20, and HPLC resulted in the isolation of twelve compounds. Their structures were identified as: epicatechin-(4β→1′, 2→O→2′)-phloroglucinol( 1 ), proanthocyanidin A-1( 2 ), proanthocyanidin A-2( 3 ), epicatechin( 4 ), phlorizin( 5 ), eriodictyol( 6 ), erythro-guaiacylglycerol-8-O-4′-(coniferyl alcohol)ether( 7 ), threo-guaiacylglycerol-8-O-4′-(coniferyl alcohol)ether( 8 ), erythro-guaiacylglycerol-8-O-4′-(sinapyl alcohol)ether( 9 ), threo-syringylglycerol-8-O-4′-(sinapyl alcohol)ether( 10 ), burselignan( 11 )and icariol A₂( 12 ). Compounds 1 to 12 were all isolated from this plant for the first time, and compound 1 was a new natural product.
- Uvaria grandiflora,
- chemical constituents,
- lignanoids,
- flavanols,
- isolation,
- identification

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