Chemical constituents of<i> Uvaria grandiflora</i>

ZHU Qian; HUANG Qilong; ZHANG Chunlei; CAO Zhengyu

doi:10.11665/j.issn.1000-5048.20190605

Journal of China Pharmaceutical University > 2019 > 50(6): 666-671. > DOI: 10.11665/j.issn.1000-5048.20190605

ZHU Qian, HUANG Qilong, ZHANG Chunlei, CAO Zhengyu. Chemical constituents of Uvaria grandiflora[J]. Journal of China Pharmaceutical University, 2019, 50(6): 666-671. DOI: 10.11665/j.issn.1000-5048.20190605

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Chemical constituents of Uvaria grandiflora

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Abstract

Chemical investigation of the roots of Uvaria grandiflora by repeated column chromatography(CC)over silica gel, ODS, Sephadex LH-20, and HPLC resulted in the isolation of twelve compounds. Their structures were identified as: epicatechin-(4β→1′, 2→O→2′)-phloroglucinol( 1 ), proanthocyanidin A-1( 2 ), proanthocyanidin A-2( 3 ), epicatechin( 4 ), phlorizin( 5 ), eriodictyol( 6 ), erythro-guaiacylglycerol-8-O-4′-(coniferyl alcohol)ether( 7 ), threo-guaiacylglycerol-8-O-4′-(coniferyl alcohol)ether( 8 ), erythro-guaiacylglycerol-8-O-4′-(sinapyl alcohol)ether( 9 ), threo-syringylglycerol-8-O-4′-(sinapyl alcohol)ether( 10 ), burselignan( 11 )and icariol A₂( 12 ). Compounds 1 to 12 were all isolated from this plant for the first time, and compound 1 was a new natural product.
- Uvaria grandiflora,
- chemical constituents,
- lignanoids,
- flavanols,
- isolation,
- identification

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[1]	Editorial Board of the Flora of China.Flora of China(中国植物志)[M].Beijing:Science Press,1979,3(2):26.
[2]	Ho DV,Kodama T,Le HTB,et al.A new polyoxygenated cyclohexene and a new megastigmane glycoside from Uvaria grandiflora[J].Bioorg Med Chem Lett,2015,25(16):3246-3250.
[3]	Ankisetty S,ElSohly HN,Li XC,et al.Aromatic constituents of Uvaria grandiflora[J].J Nat Prod,2006,69(4):692-694.
[4]	Chen RY,Zhang HL.Advances in phytochemistry of Asteraceae[C].2001′ Proceedings of the National Academic Forum of Medicinal Plants and Traditional Chinese Medicine Symposium,2001:51-55.
[5]	Hu YZR.The chemical constituents of Uvaria grandiflora and Sibiraea angustata(山椒子和窄叶鲜卑花化学成分的研究)[D].Chengdu:University of Electronic Science and Technology of China,2017.
[6]	Seangphakdee P,Pompimon W,Meepowpan P,et al.Anti-inflammatory and anticancer activities of(-)-zeylenol from stems of Uvaria grandiflora[J].ScienceAsia,2013,39(6):610.
[7]	Sharma PK,Romanczyk LJ,Kondaveti L,et al.Total synthesis of proanthocyanidin A1,A2,and their stereoisomers[J].Org Lett,2015,17(10):2306-2309.
[8]	Lou H,Sasaki TM,Tanaka H,et al.A-type proanthocyanidins from peanut skins[J].Phytochemistry,1999,51(2):297-308.
[9]	Hu J,Chen J,Zhao Y,et al.Chemical constituents from fruit hulls of Garcinia mangostana(Cuttiferae)[J].Acta Bot Yunnanica(云南植物研究),2006,28(3):319-322.
[10]	Jeong YC,Kang DL,Sun YP,et al.Isolation and identification of α-glucosidase inhibitors from the stem bark of the Nutgall Tree(Rhus javanica Linné)[J].J Korean Soc Appl Biol Chem,2013,56:547-552.
[11]	Qian W,Guo MH,Dan YL,et al.A new coumarin glycoside isolated from Artemisia annua[J].Chin Tradit Herb Drugs(中草药)2018,49(13):2953-2958.
[12]	Lourith N,Katayama T,Suzuki T.Stereochemistry and biosynthesis of 8-O-4′neolignans in Eucommia ulmoides:diastereoselective formation of guaiacylglycerol-8-O-4′-(sinapyl alcohol)ether[J].J Wood Sci,2005,51(4):370-378.
[13]	Jutiviboonsuk A,Zhang HJ,Tan GT,et al.Bioactive constituents from roots of Bursera tonkinensis[J].Phytochemistry,2005,66(23):2745-2751.
[14]	Peng WW,He WS,Ji MY,et al.Study on chemical constituents of 70% ethanol extract of Breynia fruticosa[J].China Pharm(中国药房),2017,28(36):5144-5146.

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Chemical constituents of Uvaria grandiflora

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