Novel nano-scaled Mn-metal-organic framework for enhancing photodynamic therapy through overcoming tumor hypoxia

CUI Huayuan; YAO Dan; WANG Yuxiang; HU Yiqiao

doi:10.11665/j.issn.1000-5048.20190607

Journal of China Pharmaceutical University > 2019 > 50(6): 678-685. > DOI: 10.11665/j.issn.1000-5048.20190607

CUI Huayuan, YAO Dan, WANG Yuxiang, HU Yiqiao. Novel nano-scaled Mn-metal-organic framework for enhancing photodynamic therapy through overcoming tumor hypoxia[J]. Journal of China Pharmaceutical University, 2019, 50(6): 678-685. DOI: 10.11665/j.issn.1000-5048.20190607

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Novel nano-scaled Mn-metal-organic framework for enhancing photodynamic therapy through overcoming tumor hypoxia

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A Mn-clusters-porphyrin metal-organic framework nanosheet(nMn-MOF)was synthesized by coordination chelation to enhance photodynamic therapy. The nanosheet was characterized by dynamic light scattering, transmission electron microscopy and X-ray photoelectron spectroscopy. Oxygen sensor and ICG were used to investigate the production of oxygen and the singlet oxygen(¹O₂)generation. The cytotoxicity of the nanosheet against tumor cells were detected by CCK-8 assay, and the anti-hypoxia and oxygen-generation ability of nanosheets were investigated by fluorescence staining assay. The results indicated that this nanosheet could catalyze the intracellular H₂O₂ into O₂, which overcame the tumor hypoxia. Furthermore, the generated oxygen was converted to cytotoxic ¹O₂ under the near infrared light irradiation, thereby enhancing photodynamic therapy.
- Mn-metal-organic framework,
- porphyrin,
- photodynamic therapy,
- oxygen,
- antitumor

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