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ZHENG Binbin, ZHANG Jianan, FAN Yixin, HU Liang, LIU Wentao, WANG Xuerong. Lidocaine attenuates LPS-induced acute lung injury in mice via an inhibition on matrix metalloproteinases[J]. Journal of China Pharmaceutical University, 2020, 51(2): 180-184. DOI: 10.11665/j.issn.1000-5048.20200208
Citation: ZHENG Binbin, ZHANG Jianan, FAN Yixin, HU Liang, LIU Wentao, WANG Xuerong. Lidocaine attenuates LPS-induced acute lung injury in mice via an inhibition on matrix metalloproteinases[J]. Journal of China Pharmaceutical University, 2020, 51(2): 180-184. DOI: 10.11665/j.issn.1000-5048.20200208
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Lidocaine attenuates LPS-induced acute lung injury in mice via an inhibition on matrix metalloproteinases

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  • The aim of the present study was to investigate the effects and mechanisms of lidocaine on lipopolysaccharide(LPS)-induced matrix metalloproteinase(MMP)-9 and MMP-2 activity in plasma, and the effects of lidocaine on LPS-induced acute lung injury(ALI). Mice were pretreated with lidocaine(2, 4, 8 mg/kg )for 30 minutes, and then treated with 10 mg/kg LPS(ip)for 12 h to induce ALI. The 7-day survival rate and lung wet/dry weight ratio of mice were monitored. Phosphorylation level of p38 was measured by western blot. The activity of MMP-9 and MMP-2 in plasma was evaluated by gelatin zymography. The results showed that pretreatment with lidocaine could significantly reduce the death rate of ALI mice as well as the lung wet/dry weight ratio in a dose-dependent manner and suppress the activity of MMP-9 and MMP-2 in plasma. Moreover, lidocaine also markedly inhibited LPS-induced upregulation of p-p38 in a dose-dependent manner. In conclusion, lidocaine alleviated LPS-induced acute lung injury by suppressing MMP-9 and MMP-2 activity.
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