Research progress of ERK small molecule inhibitors

LIANG Tingting; WANG Wenjie; HE Guangchao; HE Guangchao; XU Yungen

doi:10.11665/j.issn.1000-5048.20200302

Journal of China Pharmaceutical University > 2020 > 51(3): 260-269. > DOI: 10.11665/j.issn.1000-5048.20200302

LIANG Tingting, WANG Wenjie, HE Guangchao, HE Guangchao, XU Yungen. Research progress of ERK small molecule inhibitors[J]. Journal of China Pharmaceutical University, 2020, 51(3): 260-269. DOI: 10.11665/j.issn.1000-5048.20200302

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Research progress of ERK small molecule inhibitors

Funds: This study was supported by the Undergraduate Innovation and Entrepreneurship Training Program of China Pharmaceutical University (No. 201910316099)

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Received Date: November 11, 2019
Revised Date: May 10, 2020

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Abstract

Abstract

Extracellular signal-regulated kinase (ERK) is a kind of serine/threonine protein kinase. As a key downstream protein in RAS-RAF-MEK-ERK signaling pathway, its abnormal activation plays an important role in the development of tumors. Selective ERK1/2 inhibitors can block ERK signaling pathway while overcoming drug resistance caused by upstream target mutation. In this paper, the components of MAPK signaling pathway, the structure and functions of ERK and the role of ERK signaling pathway in tumor development are summarized, and some representative ERK inhibitors in clinical or preclinical studies are emphasized.

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References

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