• 中国精品科技期刊
  • 中国高校百佳科技期刊
  • 中国中文核心期刊
  • 中国科学引文数据库核心期刊
Advanced Search
SU Rina, FAN Wanjun, ZHANG Ziqiang, HE Shuwang, YAO Jing. Preparation and evaluation of azithromycin-loaded microspheres for oral administration[J]. Journal of China Pharmaceutical University, 2020, 51(3): 299-304. DOI: 10.11665/j.issn.1000-5048.20200307
Citation: SU Rina, FAN Wanjun, ZHANG Ziqiang, HE Shuwang, YAO Jing. Preparation and evaluation of azithromycin-loaded microspheres for oral administration[J]. Journal of China Pharmaceutical University, 2020, 51(3): 299-304. DOI: 10.11665/j.issn.1000-5048.20200307
shu

Preparation and evaluation of azithromycin-loaded microspheres for oral administration

Funds: This study was supported by the National Science and Technology Major Project (No. 2018ZX09721003-007-005)
More Information
  • Received Date: February 04, 2020
  • Revised Date: May 17, 2020
    Graphical Abstract
    • Abstract
  • To mask the bitterness of azithromycin（AZI） and improve patient compliance, an AZI-loaded microsphere (AZI-EC MS) for oral administration was prepared by O/W emulsion solvent evaporation with ethylcellulose (EC) as carrier. The release profiles and taste-masking effect of AZI-EC MS were preliminarily assessed. Its physical properties and morphology were then investigated by differential scanning calorimetry (DSC), Fourier-transform infrared spectroscopy (FTIR) and scanning electron microscope (SEM). The results indicated that the polymer weight of EC could influence the drug release behavior. With a drug polymer ratio of 1∶1 and mixed EC (N22/T10, 7∶3) as carrier, the cumulative release of AZI-EC MS at 0.5 h was less than 40% and reached 90% at 8 h; the drug loading efficiency of microspheres was (48.95 ± 0.86)% with smooth spherical morphology. The AZI bitterness threshold is 9.93 μg/mL with a strong bitter taste, which indicated a better taste masking effect. Therefore, AZI-EC MS prepared in this study can mask AZI bitterness and improve patient compliance, setting the stage for the research of new AZI preparations.
    • FullText(HTML)
    • References (12)
  • [1]
    . Profiles Drug Subst Excip Relat Methodol， 2014， 39：1-40.
    [2]
    Hansen MP， Scott AM， McCullough A， et al. Adverse events in people taking macrolide antibiotics versus placebo for any indication［J］. Cochrane Database Syst Rev， 2019， 1：CD011825.
    [3]
    Walsh J， Cram A， Woertz K， et al. Playing hide and seek with poorly tasting paediatric medicines：do not forget the excipients［J］. Adv Drug Deliv Rev， 2014， 73：14-33.
    [4]
    Lopez FL， Ernest TB， Tuleu C， et al. Formulation approaches to pediatric oral drug delivery：benefits and limitations of current platforms［J］. Expert Opin Drug Deliv， 2015， 12（11）：1727-1740.
    [5]
    Ivanovska V， Rademaker CM， van Dijk L， et al. Pediatric drug formulations：a review of challenges and progress［J］. Pediatrics， 2014， 134（2）：361-372.
    [6]
    Mistry P， Batchelor H. Evidence of acceptability of oral paediatric medicines：a review［J］. J Pharm Pharmacol， 2017， 69（4）：361-376.
    [7]
    Sun JD，Zhang ZQ，He SW，et al.Progress on novel pediatric oral solid dosage forms［J］.J China Pharm Univ（中国药科大学学报），2019，50（6）：631-640.
    [8]
    Lopez FL， Mistry P， Batchelor HK， et al. Acceptability of placebo multiparticulate formulations in children and adults［J］. Sci Rep， 2018， 8（1）：9210.
    [9]
    Gandhi R， Kaul CL， Panchagnula R. Pharmacokinetic evaluation of an azithromycin controlled release dosage form in healthy human volunteers：a single dose study［J］. Int J Pharm， 2004， 270（1/2）：1-8.
    [10]
    Curatolo W. Interdisciplinary science and the design of a single-dose antibiotic therapy［J］. Pharm Res， 2011， 28（9）：2059-2071.
    [11]
    Kharb V， Saharan VA， Dev K， et al. Formulation， evaluation and 3（2） full factorial design-based optimization of ondansetron hydrochloride incorporated taste masked microspheres［J］. Pharm Dev Technol， 2014， 19（7）：839-852.
    [12]
    Pein M， Preis M， Eckert C， et al. Taste-masking assessment of solid oral dosage forms：a critical review［J］. Int J Pharm， 2014， 465（1/2）：239-254.
    • Related Articles

  • Related Articles

    [1]DONG Wujun, FU Qiang, LYU Huixia. Surface solid dispersion of honokiol-croscarmellose sodium:preparation and characterization[J]. Journal of China Pharmaceutical University, 2019, 50(4): 417-422. DOI: 10.11665/j.issn.1000-5048.20190406
    [2]GUO Jinxiu, CHENG Juan, XIE Jun, HUANG Chunyu, ZHOU Jianping. Comparative studies on characteristics of microcrystalline cellulose in pelletization[J]. Journal of China Pharmaceutical University, 2014, 45(5): 551-556. DOI: 10.11665/j.issn.1000-5048.20140508
    [3]HAN Peng, CHEN Fangcheng, TU Jiasheng. Flowability evaluation of silicified microcrystalline cellulose[J]. Journal of China Pharmaceutical University, 2013, 44(5): 416-420. DOI: 10.11665/j.issn.1000-5048.20130506
    [4]DI Bin, ZHAO Jing-dan, FENG Fang, SU Meng-xiang. Preparation and application of immobilized chiral stationary phase bonded cellulose[J]. Journal of China Pharmaceutical University, 2009, 40(5): 431-434.
    [5]A Computer Simulation of Miscibility of 5-aminosalicylic Acid with Ethyl Cellulose[J]. Journal of China Pharmaceutical University, 2000, (6): 29-33.
    [6]Study onDrug Release Characteristics from Aqueous Ethylcellulose Dispersion Coated Pellets[J]. Journal of China Pharmaceutical University, 2000, (1): 27-30.
    [7]Sustained Release Solid Dispersions of Ketoprofen with Ethylcellulose[J]. Journal of China Pharmaceutical University, 1999, (3): 32-35.
    [8]Preparation and Evaluation of Ethylcellulose Latex[J]. Journal of China Pharmaceutical University, 1998, (2): 31-33.
    [10]Zhao Tihui, Chen Yuying, Zhang Ji, Qian Junbin, Yu Jialin. DETERMINATION OF VITAMIN U IN TABLETS BY MICROCELLULOSE TLC SCANNING METHOD[J]. Journal of China Pharmaceutical University, 1982, (2): 10-13.

  • Cited by

    Periodical cited type(4)

    1. 胡燕超，李梦然，张子贺，张浩，李席. 静电喷雾法制备乙基纤维素/红霉素复合物. 蚌埠学院学报. 2024(02): 5-8 .
    2. 周密，朱小龙，李席. 静电喷雾法制备乙基纤维素/阿奇霉素复合物. 九江学院学报(自然科学版). 2022(01): 89-92 .
    3. 王倩，吴新安，何广卫，苏峰. 磷酸二甲啡烷微球口腔速溶膜剂的制备及质量评价. 齐齐哈尔医学院学报. 2022(19): 1849-1854 .
    4. 杨保德，王传虎. 阿奇霉素/乙基纤维素复合物的静电喷雾法制备及表征. 山东化工. 2021(14): 53-54+56 .

    Other cited types(3)

Catalog

    Get Citation
    PDF
    XML
    Article views (237) PDF downloads (506) Cited by(7)
    Turn off MathJax
    Article Contents
    Abstract
    References
    Related Articles

    Copyright © Journal of China Pharmaceutical University苏ICP备12050101号-2

    Address：24 Tongjia Lane, Nanjing City, Jiangsu Province （210009）Tel: 025-83271566E-mail: xuebao@cpu.edu.cn

    Supported by: Beijing Renhe Information Technology Co., Ltd.  Baidu Analytics

    Total visits：297285

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return