Advances of DNA-based nanomaterials in tumor therapy

CHEN Ye; YIN Jun; YAO Wenbing; GAO Xiangdong

doi:10.11665/j.issn.1000-5048.20200404

Journal of China Pharmaceutical University > 2020 > 51(4): 406-417. > DOI: 10.11665/j.issn.1000-5048.20200404

CHEN Ye, YIN Jun, YAO Wenbing, GAO Xiangdong. Advances of DNA-based nanomaterials in tumor therapy[J]. Journal of China Pharmaceutical University, 2020, 51(4): 406-417. DOI: 10.11665/j.issn.1000-5048.20200404

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Advances of DNA-based nanomaterials in tumor therapy

1.
Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, China Pharmaceutical University, Nanjing 210009
2.
School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China

Funds: This study was supported by the Innovation Team of the “Double-First Class” Disciplines (No.CPU2018GF08)

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Received Date: April 22, 2020

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Abstract

Abstract

Antitumor drugs usually have deficiencies such as poor water solubility, low targeting, poor stability, and difficulty in being taken up by tumor cells. The development of an ideal drug delivery vehicle is still an urgent problem to be solved in the field of cancer therapy. Due to their excellent sequence programmability, biocompatibility and biodegradability, DNA-based nanomaterials have been widely used as drug delivery vehicles for cancer treatment. Numerous studies have shown that DNA nanomaterials can effectively load cancer therapeutic agents, and achieve tumor targeted delivery, efficient cellular internalization as well as stimuli-responsive drug release. Starting from the history and development of DNA nanotechnology, this review illustrates the application progress of DNA nanomaterial as drug delivery vehicle in chemotherapy, gene therapy, immunotherapy and photodynamic therapy, and the future development is prospected so as to provide some reference for other researchers in this field.
- DNA nanomaterials,
- drug delivery system,
- tumor,
- advances

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References

[1]	Mohammad IS, He W, Yin L. Understanding of human ATP binding cassette superfamily and novel multidrug resistance modulators to overcome MDR[J]. Biomed Pharmacother, 2018, 100: 335-348.
[2]	Liu J, Zhang Y, Zeng Q, et al. Delivery of RIPK4 small interfering RNA for bladder cancer therapy using natural halloysite nanotubes[J]. Sci Adv, 2019, 5(9): eaaw6499.
[3]	Bhaskaran V, Yao Y, Bei F, et al. Engineering, delivery, and biological validation of artificial microRNA clusters for gene therapy applications[J]. Nat Protoc, 2019, 14(12): 3538-3553.
[4]	Xu J, Sun J, Ho PY, et al. Creatine based polymer for codelivery of bioengineered microRNA and chemodrugs against breast cancer lung metastasis[J]. Biomaterials, 2019, 210: 25-40.
[5]	Chen L, Zhou L, Wang C, et al. Tumor-targeted drug and CpG delivery system for phototherapy and docetaxel-enhanced immunotherapy with polarization toward M1-type macrophages on triple negative breast cancers[J]. Adv Mater, 2019, 31(52): e1904997.
[6]	Mirza Z, Karim S. Nanoparticles-based drug delivery and gene therapy for breast cancer: recent advancements and future challenges[J]. Semin Cancer Biol, 2019. doi:10.1016/j.semcancer. 2019. 10. 020.
[7]	Zhao H, Zhao B, Wu L, et al. Amplified cancer immunotherapy of a surface-engineered antigenic microparticle vaccine by synergistically modulating tumor microenvironment[J]. ACS Nano, 2019, 13(11): 12553-12566.
[8]	Liu JN, Bu W, Shi J. Chemical design and synthesis of functionalized probes for imaging and treating tumor hypoxia[J]. Chem Rev, 2017, 117(9): 6160-6224.
[9]	Seeman NC. Nucleic acid junctions and lattices[J]. J Theor Biol, 1982, 99(2): 237-247.
[10]	Zuo H, Mao C. A minimalist's approach for DNA nanoconstructions[J]. Adv Drug Deliv Rev, 2019, 147: 22-28.
[11]	Mohsen MG, Kool ET. The discovery of rolling circle amplification and rolling circle transcription[J]. Acc Chem Res, 2016, 49(11): 2540-2550.
[12]	Hong CA, Jang B, Jeong EH, et al. Self-assembled DNA nanostructures prepared by rolling circle amplification for the delivery of siRNA conjugates[J]. Chem Commun (Camb), 2014, 50(86): 13049-13051.
[13]	Yata T, Takahashi Y, Tan M, et al. Efficient amplification of self-gelling polypod-like structured DNA by rolling circle amplification and enzymatic digestion[J]. Sci Rep, 2015, 5: 14979.
[14]	Rothemund PW. Folding DNA to create nanoscale shapes and patterns[J]. Nature, 2006, 440(7082): 297-302.
[15]	Wei B, Dai M, Yin P. Complex shapes self-assembled from single-stranded DNA tiles[J]. Nature, 2012, 485(7400): 623-626.
[16]	Seeman NC. DNA in a material world[J]. Nature, 2003, 421(6921): 427-431.
[17]	Ouyang C, Zhang S, Xue C, et al. Precision-guided missile-like DNA nanostructure containing warhead and guidance control for aptamer-based targeted drug delivery into cancer cells in vitro and in vivo[J]. J Am Chem Soc, 2020, 142(3): 1265-1277.
[18]	Di Z, Zhao J, Chu H, et al. An acidic-microenvironment-driven DNA nanomachine enables specific ATP imaging in the extracellular milieu of tumor[J]. Adv Mater, 2019, 31(33): e1901885.
[19]	Dutta PK, Zhang Y, Blanchard AT, et al. Programmable multivalent DNA-origami tension probes for reporting cellular traction forces[J]. Nano Lett, 2018, 18(8): 4803-4811.
[20]	Liu Z, Pei H, Zhang L, et al. Mitochondria-targeted DNA nanoprobe for real-time imaging and simultaneous quantification of Ca²⁺ and pH in neurons[J]. ACS Nano, 2018, 12(12): 12357-12368.
[21]	Setyawati MI, Kutty RV, Leong DT. DNA nanostructures carrying stoichiometrically definable antibodies[J]. Small, 2016, 12(40): 5601-5611.
[22]	Wu SY, Chou HY, Yuh CH, et al. Radiation-sensitive dendrimer-based drug delivery system[J]. Adv Sci (Weinh), 2018, 5(2): 1700339.
[23]	Ge Z, Guo L, Wu G, et al. DNA origami-enabled engineering of ligand-drug conjugates for targeted drug delivery[J]. Small, 2020, 16(16): e1904857.
[24]	Liu J, Song L, Liu S, et al. A tailored DNA nanoplatform for synergistic RNAi-/chemotherapy of multidrug-resistant tumors[J]. Angew Chem Int Ed Engl, 2018, 57(47): 15486-15490.
[25]	Zhao H, Yuan X, Yu J, et al. Magnesium-stabilized multifunctional DNA nanoparticles for tumor-targeted and pH-responsive drug delivery[J]. ACS Appl Mater Interfaces, 2018, 10(18): 15418-15427.
[26]	Liu J, Song L, Liu S, et al. A DNA-based nanocarrier for efficient gene delivery and combined cancer therapy[J]. Nano Lett, 2018, 18(6): 3328-3334.
[27]	Jiang Q, Song C, Nangreave J, et al. DNA origami as a carrier for circumvention of drug resistance[J]. J Am Chem Soc, 2012, 134(32): 13396-13403.
[28]	Zhang Q, Jiang Q, Li N, et al. DNA origami as an in vivo drug delivery vehicle for cancer therapy[J]. ACS Nano, 2014, 8(7): 6633-6643.
[29]	Zhang H, Ma Y, Xie Y, et al. A controllable aptamer-based self-assembled DNA dendrimer for high affinity targeting, bioimaging and drug delivery[J]. Sci Rep, 2015, 5: 10099.
[30]	Yao C, Yuan Y, Yang D. Magnetic DNA nanogels for targeting delivery and multistimuli-triggered release of anticancer drugs[J]. ACS Applied Bio Materials, 2018, 1(6): 2012-2020.
[31]	Ma Y, Wang Z, Ma Y, et al. A telomerase-responsive DNA icosahedron for precise delivery of platinum nanodrugs to cisplatin-resistant cancer[J]. Angew Chem Int Ed Engl, 2018, 57(19): 5389-5393.
[32]	Wu T, Liu J, Liu M, et al. A nanobody-conjugated DNA nanoplatform for targeted platinum-drug delivery[J]. Angew Chem Int Ed Engl, 2019, 58(40): 14224-14228.
[33]	Liu J, Wu T, Lu X, et al. A self-assembled platform based on branched DNA for sgRNA/Cas9/antisense delivery[J]. J Am Chem Soc, 2019, 141(48): 19032-19037.
[34]	Wen AM, Steinmetz NF. Design of virus-based nanomaterials for medicine, biotechnology, and energy[J]. Chem Soc Rev, 2016, 45(15): 4074-4126.
[35]	Lee H, Lytton-Jean AK, Chen Y, et al. Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery[J]. Nat Nanotechnol, 2012, 7(6): 389-393.
[36]	Roh YH, Lee JB, Shopsowitz KE, et al. Layer-by-layer assembled antisense DNA microsponge particles for efficient delivery of cancer therapeutics[J]. ACS Nano, 2014, 8(10): 9767-9780.
[37]	Chen G, Liu D, He C, et al. Enzymatic synthesis of periodic DNA nanoribbons for intracellular pH sensing and gene silencing[J]. J Am Chem Soc, 2015, 137(11): 3844-3851.
[38]	Hu Q, Li H, Wang L, et al. DNA nanotechnology-enabled drug delivery systems[J]. Chem Rev, 2019, 119(10): 6459-6506.
[39]	Rattanakiat S, Nishikawa M, Funabashi H, et al. The assembly of a short linear natural cytosine-phosphate-guanine DNA into dendritic structures and its effect on immunostimulatory activity[J]. Biomaterials, 2009, 30(29): 5701-5706.
[40]	Qu Y, Yang J, Zhan P, et al. Self-assembled DNA dendrimer nanoparticle for efficient delivery of immunostimulatory CpG motifs[J]. ACS Appl Mater Interfaces, 2017, 9(24): 20324-20329.
[41]	Li J, Pei H, Zhu B, et al. Self-assembled multivalent DNA nanostructures for noninvasive intracellular delivery of immunostimulatory CpG oligonucleotides[J]. ACS Nano, 2011, 5(11): 8783-8789.
[42]	Ouyang X, Li J, Liu H, et al. Rolling circle amplification-based DNA origami nanostructrures for intracellular delivery of immunostimulatory drugs[J]. Small, 2013, 9(18): 3082-3087.
[43]	Schuller VJ, Heidegger S, Sandholzer N, et al. Cellular immunostimulation by CpG-sequence-coated DNA origami structures[J]. ACS Nano, 2011, 5(12): 9696-9702.
[44]	Wang C, Sun W, Wright G, et al. Inflammation-triggered cancer immunotherapy by programmed delivery of CpG and anti-PD1 antibody[J]. Adv Mater, 2016, 28(40): 8912-8920.
[45]	Zhuang X, Ma X, Xue X, et al. A photosensitizer-loaded DNA origami nanosystem for photodynamic therapy[J]. ACS Nano, 2016, 10(3): 3486-3495.
[46]	Chang K, Tang Y, Fang X, et al. Incorporation of porphyrin to pi-conjugated backbone for polymer-dot-sensitized photodynamic therapy[J]. Biomacromolecules, 2016, 17(6): 2128-2136.
[47]	Park J, Jiang Q, Feng D, et al. Size-controlled synthesis of porphyrinic metal-organic framework and functionalization for targeted photodynamic therapy[J]. J Am Chem Soc, 2016, 138(10): 3518-3525.
[48]	Shieh YA, Yang SJ, Wei MF, et al. Aptamer-based tumor-targeted drug delivery for photodynamic therapy[J]. ACS Nano, 2010, 4(3): 1433-1442.
[49]	Yang Y, Zhu W, Feng L, et al. G-quadruplex-based nanoscale coordination polymers to modulate tumor hypoxia and achieve nuclear-targeted drug delivery for enhanced photodynamic therapy[J]. Nano Lett, 2018, 18(11): 6867-6875.
[50]	Auvinen H, Zhang H, Nonappa, et al. Protein coating of DNA nanostructures for enhanced stability and immunocompatibility[J]. Adv Healthc Mater, 2017, 6(18):1700692.

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