A method for the synthesis of chalcones

LUO Weixian; YANG Lishou; YANG Xiaosheng

doi:10.11665/j.issn.1000-5048.20200501

LUO Weixian, YANG Lishou, YANG Xiaosheng. A method for the synthesis of chalcones[J]. Journal of China Pharmaceutical University, 2020, 51(5): 509-513. DOI: 10.11665/j.issn.1000-5048.20200501

Citation:

LUO Weixian, YANG Lishou, YANG Xiaosheng. A method for the synthesis of chalcones[J]. Journal of China Pharmaceutical University, 2020, 51(5): 509-513. DOI: 10.11665/j.issn.1000-5048.20200501

Citation:

LUO Weixian, YANG Lishou, YANG Xiaosheng. A method for the synthesis of chalcones[J]. Journal of China Pharmaceutical University, 2020, 51(5): 509-513. DOI: 10.11665/j.issn.1000-5048.20200501

A method for the synthesis of chalcones

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In this paper,a new method for catalytic synthesis of chalcones from substituted acetophenone and substituted benzaldehyde in polyphosphoric acid/concentrated sulfuric acid system was proposed,and the reaction conditions were optimized. The results showed that the optimized reaction conditions were determined as polyphosphoric acid of 5 equiv. and concentrated sulfuric acid of 20 equiv.,with 1,4-dioxane as solvent at 90 °C for 2 h under nitrogen protection. Twelve chalcones were synthesized with good yield. All target compounds were characterized by IR,HRMS,¹H NMR and ¹³C NMR.

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A method for the synthesis of chalcones

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