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LUO Weixian, YANG Lishou, YANG Xiaosheng. A method for the synthesis of chalcones[J]. Journal of China Pharmaceutical University, 2020, 51(5): 509-513. DOI: 10.11665/j.issn.1000-5048.20200501
Citation: LUO Weixian, YANG Lishou, YANG Xiaosheng. A method for the synthesis of chalcones[J]. Journal of China Pharmaceutical University, 2020, 51(5): 509-513. DOI: 10.11665/j.issn.1000-5048.20200501
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A method for the synthesis of chalcones

Funds: The study was supported by the National Natural Science Foundation of China(No.81860609),the Natural Science Foundation of Guizhou Province(No.QKHJC[2019]1213),and the High-level Innovative Talents Training in Guizhou Province(No.QKHRC[2015]4027)
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  • Received Date: April 24, 2020
  • Revised Date: September 10, 2020
    Graphical Abstract
    • Abstract
  • In this paper,a new method for catalytic synthesis of chalcones from substituted acetophenone and substituted benzaldehyde in polyphosphoric acid/concentrated sulfuric acid system was proposed,and the reaction conditions were optimized. The results showed that the optimized reaction conditions were determined as polyphosphoric acid of 5 equiv. and concentrated sulfuric acid of 20 equiv.,with 1,4-dioxane as solvent at 90 °C for 2 h under nitrogen protection. Twelve chalcones were synthesized with good yield. All target compounds were characterized by IR,HRMS,1H NMR and 13C NMR.
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    • References (18)
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