Effect of Artemisia Argyi Folium ethanolic<i> </i>extract on blood glucose and blood lipids in diabetic mice

XIAO Jianqi; XU Jian; SHU Fangrong; HU Xiaofen; LIU Wenyuan; FENG Feng

doi:10.11665/j.issn.1000-5048.20210110

Journal of China Pharmaceutical University > 2021 > 52(1): 71-76. > DOI: 10.11665/j.issn.1000-5048.20210110

XIAO Jianqi, XU Jian, SHU Fangrong, HU Xiaofen, LIU Wenyuan, FENG Feng. Effect of Artemisia Argyi Folium ethanolic extract on blood glucose and blood lipids in diabetic mice[J]. Journal of China Pharmaceutical University, 2021, 52(1): 71-76. DOI: 10.11665/j.issn.1000-5048.20210110

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Effect of Artemisia Argyi Folium ethanolic extract on blood glucose and blood lipids in diabetic mice

1.
Department of Pharmacy, Jiangsu Food and Pharmaceutical Science College, Huaian 223003
2.
Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 211198
3.
Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, China

Funds: The study was supported by the Natural Science Foundation of Huai"an of Jiangsu Province (No.HAB202066) and the General Program Foundation of Jiangsu Food and Pharmaceutical Science College (No.JSFP2019003, No.JSFP2019009)

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Received Date: July 08, 2020
Revised Date: December 24, 2020

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Abstract

Abstract

To investigate the effect of ethanolic extract from Artemisia Argyi Folium on blood glucose and blood lipids in diabetic mice, ICR mice were induced by intraperitoneal injection of 35 mg/kg streptozotocin (STZ) and a high-carbohydrate/high-fat diet to construct type 2 diabetes mellitus model. Diabetic mice were randomly divided into three groups: the model group (5 mL/kg 0.5% CMC-Na), the Artemisia Argyi Folium ethanolic extract low-dose group (100 mg/kg ) and high-dose group (400 mg/kg ). During the treatment for 6 weeks, the amount of drinking water and food intake of mice were recorded every day. Blood glucose and body weight were recorded every week. After treatment for 6 weeks, serum total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C),and oral glucose tolerance (OGTT) were measured. The results showed that the amount of drinking water and food intake of mice significantly decreased (P < 0.01) in the Artemisia Argyi Folium ethanolic extract high-dose group; oral glucose tolerance was significantly improved (P < 0.01) and the contents of TC, TG and LDL-C were significantly decreased in the Artemisia Argyi Folium ethanolic extract low-dose group (P < 0.01). The ethanolic extract from Artemisia Argyi Folium could significantly improve the glucose and lipid metabolic disorder in T2DM mice in a dose-dependent manner.
- Artemisia Argyi Folium,
- ethanolic extract,
- T2DM,
- blood glucose,
- blood lipids

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