Effects of <i>S</i>-oxiracetam on learning and memory impairment in mice

FAN Wenxiang; LI Xiaomin; XU Chi

doi:10.11665/j.issn.1000-5048.20210111

Journal of China Pharmaceutical University > 2021 > 52(1): 77-83. > DOI: 10.11665/j.issn.1000-5048.20210111

FAN Wenxiang, LI Xiaomin, XU Chi. Effects of S-oxiracetam on learning and memory impairment in mice[J]. Journal of China Pharmaceutical University, 2021, 52(1): 77-83. DOI: 10.11665/j.issn.1000-5048.20210111

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Effects of S-oxiracetam on learning and memory impairment in mice

1.
Department of Pharmacy, Zhongda Hospital, Southeast University, Nanjing 210009
2.
Department of Neurobiology and Acupuncture Research, The 3rd Clinical College of Zhejiang Chinese Medical University, Hangzhou 310053, China

Funds: This work was supported by the National Natural Science Foundation of China (No.81701313) and the Fundamental Research Funds for the Central Universities (No.2242020K40175)

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Received Date: July 28, 2020
Revised Date: November 24, 2020

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Abstract

Abstract

To investigate the effects and possible molecular mechanism of S-oxiracetam(S-ORC) on learning and memory impairment in mice, mice were divided into 5 groups, control group, model group, high-dose of S-ORC (0.96 g/kg), medium-dose of S-ORC (0.48 g/kg) and low-dose of S-ORC (0.24 g/kg) treatment groups.Step-down test and Y-maze test were used to investigate the effects of S-ORC on the brain.The results of step-down test revealed that the mice in high and medium-dose groups could significantly decrease the reaction time, fault times and prolong the incubation periods of memory compared with the model group.Compared with the model group, the fault times of mice in high and medium-dose groups decreased significantly and the right times to find the safety increased significantly in Y-maze test.Furthermore, through treatment with S-ORC (high and medium-dose groups), the content of Ach in mice brain was significantly higher than that in model group, and the level of AChE decreased significantly.The above results suggest that the underlying mechanism of S-ORC on learning and memory impairment in mice may include the amelioration of the central cholinergic nervous system.
- S-oxiracetam,
- learning and memory,
- step-down test,
- Y-maze test

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[1]	. Eur J Neurol， 2018， 25（1）： 59-70.
[2]	Rabiei Z， Setorki M. Effect of hydroalcoholic Echium amoenum extract on scopolamine-induced learning and memory impairment in rats［J］. Pharm Biol， 2018， 56（1）： 672-677.
[3]	Hlinák Z， Krejcí I. Oxiracetam pre- but not post-treatment prevented social recognition deficits produced with trimethyltin in rats［J］. Behav Brain Res， 2005， 161（2）： 213-219.
[4]	Wang CY， Li FQ， Guan Y， et al. Bone marrow stromal cells combined with oxiracetam influences the expression of B-cell lymphoma 2 in rats with ischemic stroke［J］. J Stroke Cerebrovasc Dis， 2014， 23（10）： 2591-2597.
[5]	Gouliaev AH， Senning A. Piracetam and other structurally related nootropics［J］. Brain Res Brain Res Rev， 1994， 19（2）： 180-222.
[6]	Zhang QY， Yang W， Yang Y， et al. Comparative pharmacokinetic studies of racemic oxiracetam and its pure enantiomers after oral administration in rats by a stereoselective HPLC method［J］. J Pharm Biomed Anal， 2015， 111： 153-158.
[7]	Zhang QY， Yang W， Zhang Q， et al. Enantioselective HPLC determination of oxiracetam enantiomers and application to a pharmacokinetic study in beagle dogs［J］. J Chromatogr B Analyt Technol Biomed Life Sci， 2015， 993/994： 9-13.
[8]	Fan WX， Li X， Huang LL， et al. S-oxiracetam ameliorates ischemic stroke induced neuronal apoptosis through up-regulating α7 nAChR and PI3K/Akt/GSK3β signal pathway in rats［J］. Neurochem Int， 2018， 115： 50-60.
[9]	Huang LL， Shang EX， Fan WX， et al. S-oxiracetam protect against ischemic stroke via alleviating blood brain barrier dysfunction in rats［J］. Eur J Pharm Sci， 2017， 109： 40-47.
[10]	Gong XJ， Rong ZT， Zhang LD， et al. Antagonism effect of ginkgolides on vascular dementia［J］.Chin J Nat Med（中国天然药物）， 2008， 6（3）：227-231.
[11]	Chen F， Dong RR， Zhong KL， et al. Antidiabetic drugs restore abnormal transport of amyloid-β across the blood-brain barrier and memory impairment in db/db mice［J］. Neuropharmacology， 2016， 101： 123-136.
[12]	Yao WB， Wang H， Shi J， et al. Improving effect of CoQ₁₀ on learning and memory ability in animals［J］. J China Pharm Univ（中国药科大学学报）， 2004， 35（1）：73-76.
[13]	Lin CZ， Chen DJ， Ning Y， et al. Research on effects of phenylethanoid glycosides of Callicarpa kochiana on learning and memory function in multiple models［J］. Pharmacol Clin Chin Mater Med（中药药理与临床）， 2013， 29（1）：72-74.
[14]	Sohn E， Lim HS， Kim YJ，et al. Elaeagnus glabra f. oxyphylla attenuates scopolamine-induced learning and memory impairments in mice by improving cholinergic transmission via activation of CREB/NGF signaling［J］. Nutrients， 2019， 11（6）：1205-1219.
[15]	Han YF， Yang HY， Li LB， et al. Schisanhenol improves learning and memory in scopolamine-treated mice by reducing acetylcholinesterase activity and attenuating oxidative damage through SIRT1-PGC-1α-Tau signaling pathway［J］. Int J Neurosci， 2019， 129（2）： 110-118.
[16]	Zhi DG， Pang JP， Jin ZX， et al. Improvement of Haima Bushen Pills on learning and memory impairment in mice［J］. Drugs Clinic（现代药物与临床）， 2019， 34（5）：1290-1293.
[17]	Yuan R， Zhang YH， Wang Y， et al. Effect of Qinggong Shoutao pill on learning and memorying dysmnesia mice［J］. Chin J Integr Med（中国中西医结合杂志）， 2019， 39（1）：88-91.

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