• 中国精品科技期刊
  • 中国高校百佳科技期刊
  • 中国中文核心期刊
  • 中国科学引文数据库核心期刊
Advanced Search
DAI Jiangdong, LI Huipeng, SUN Minjie. Effects of polyethylene glycol length on oral absorption of coumarin 6-loaded nanostructured lipid carrier[J]. Journal of China Pharmaceutical University, 2021, 52(3): 293-300. DOI: 10.11665/j.issn.1000-5048.20210305
Citation: DAI Jiangdong, LI Huipeng, SUN Minjie. Effects of polyethylene glycol length on oral absorption of coumarin 6-loaded nanostructured lipid carrier[J]. Journal of China Pharmaceutical University, 2021, 52(3): 293-300. DOI: 10.11665/j.issn.1000-5048.20210305
shu

Effects of polyethylene glycol length on oral absorption of coumarin 6-loaded nanostructured lipid carrier

  • 1.

    Jiangsu Jianhu People's Hospital,Yancheng 224700

  • 2.

    Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China

Funds: This study was supported by the National Natural Science Foundation of China (No.81872817) and the "Double First-Class" University Project of China Pharmaceutical University (No. CPU2018GY07)
More Information
  • Received Date: July 14, 2020
  • Revised Date: May 25, 2021
    Graphical Abstract
    • Abstract
  • Polyethylene glycol (PEG) of different lengths were prepared to investigate their effects on oral absorption of nanostructured lipid carrier (NLCs).Three kinds of PEG-modified NLCs with different chain lengths, including polyethylene glycol (100) monostearate (S100), polyethylene glycol (55) monostearate (S55), polyethylene glycol (40) monostearate (S40), were prepared by film dispersion method.Coumarin 6 was chosen as a fluorescent probe to characterize the physicochemical properties of NLCs with different lengths.Meanwhile, the stability of NLCs in simulate buffer, the release behavior, cytotoxicity of NLCs, the uptake kinetics and cellular uptake mechanisms were evaluated. This work demonstrated that the thickness of the hydrated layer increased with the increase of PEG length. Of note, S100-modified NLCs (pNLC-EG100) exhibited higher cellular uptake efficiency compared with other formulations. Thus, S100 was optimized as the best molecular weight for PEG-modified NLCs on oral drug delivery system.
    • FullText(HTML)
    • References (14)
  • [1]
    . Pharmaceutics，2019，11（3）：E129.
    [2]
    Date AA，Hanes J，Ensign LM. Nanoparticles for oral delivery：Design，evaluation and state-of-the-art［J］. J Control Release，2016，240：504-526.
    [3]
    Khosa A，Reddi S，Saha RN. Nanostructured lipid carriers for site-specific drug delivery［J］. Biomed Pharmacother，2018，103：598-613.
    [4]
    Garbuzenko OB，Kbah N，Kuzmov A，et al. Inhalation treatment of cystic fibrosis with lumacaftor and ivacaftor co-delivered by nanostructured lipid carriers［J］. J Control Release，2019，296：225-231.
    [5]
    Ensign LM，Cone R，Hanes J. Oral drug delivery with polymeric nanoparticles：the gastrointestinal mucus barriers［J］. Adv Drug Deliv Rev，2012，64（6）：557-570.
    [6]
    Takeuchi H，Yamamoto H，Niwa T，et al. Enteral absorption of insulin in rats from mucoadhesive chitosan-coated liposomes［J］. Pharm Res，1996，13（6）：896-901.
    [7]
    Alp G，Aydogan N. Lipid-based mucus penetrating nanoparticles and their biophysical interactions with pulmonary mucus layer［J］. Eur J Pharm Biopharm，2020，149：45-57.
    [8]
    Lai SK，Wang YY，Hanes J. Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues［J］. Adv Drug Deliv Rev，2009，61（2）：158-171.
    [9]
    Huckaby JT，Lai SK. PEGylation for enhancing nanoparticle diffusion in mucus［J］. Adv Drug Deliv Rev，2018，124：125-139.
    [10]
    Tan XY，Zhang Y，Wang Q，et al. Cell-penetrating peptide together with PEG-modified mesostructured silica nanoparticles promotes mucous permeation and oral delivery of therapeutic proteins and peptides［J］. Biomater Sci，2019，7（7）：2934-2950.
    [11]
    Li HP，Su ZG，Chen ML，et al. Preparation and characterization of nanostructured lipid carriers with difference in particle size［J］. J China Pharm Univ（中国药科大学学报），2015，46（4）：436-443.
    [12]
    Sadzuka Y，Nakade A，Hirama R，et al. Effects of mixed polyethyleneglycol modification on fixed aqueous layer thickness and antitumor activity of doxorubicin containing liposome［J］. Int J Pharm，2002，238（1/2）：171-180.
    [13]
    Allard-Vannier E，Hervé-Aubert K，Kaaki K，et al. Folic acid-capped PEGylated magnetic nanoparticles enter cancer cells mostly via clathrin-dependent endocytosis［J］. Biochim Biophys Acta Gen Subj，2017，1861（6）：1578-1586.
    [14]
    Wang XY，Wang XY，Qiu LZ，et al. Cytotoxicity and cellular uptake of paclitaxel-loaded carboxymethyl chitosan-Rhein polymeric micelles in MCF-7 cells［J］. J China Pharm Univ（中国药科大学学报），2020，51（1）：33-37.
    • Related Articles

  • Related Articles

    [1]LI Qiang, WANG Wendie, JIA Yue, ZHENG Yuzhao, ZHOU Jianping, YIN Tingjie. Effect of solubilizing strategies on oral absorption of felodipine[J]. Journal of China Pharmaceutical University, 2021, 52(2): 195-202. DOI: 10.11665/j.issn.1000-5048.20210208
    [2]ZENG Ye, ZHOU Zixuan, SUN Xun. Preparation of sheddable PEG modified miRNA-complexing nanoparticles and its preliminary in vitro and in vivo study[J]. Journal of China Pharmaceutical University, 2016, 47(6): 702-707. DOI: 10.11665/j.issn.1000-5048.20160612
    [3]Everted Gut Sac as a Technique to Study the Absorption Behavior of Cyclosporin A Nanoliposome[J]. Journal of China Pharmaceutical University, 2003, (2): 41-44.
    [4]Absorption of Breviscapine in Small Intestine of Rat[J]. Journal of China Pharmaceutical University, 2003, (1): 67-71.
    [5]Studies on the Absorption Kinetics of Diltiazem Hydrochloride and its Significance Oral Dosage Form Design[J]. Journal of China Pharmaceutical University, 1998, (3): 29-32.
    [6]Studies on Absorptive Mechanism of Insulin in Oral Microemulsion[J]. Journal of China Pharmaceutical University, 1997, (6): 9-11.
    [7]Studies of Absorption Mechanism and the Best Absorption Segment of Erythromycin in situ[J]. Journal of China Pharmaceutical University, 1997, (1): 17-22.
    [8]Content Determination of Cu,Co,Mn,Fe in TOTHEMA Oral Ampoules by AAS[J]. Journal of China Pharmaceutical University, 1996, (6): 42-44.
    [9]Studies on the Shelflife of Cephalexin Oral Suspension[J]. Journal of China Pharmaceutical University, 1992, (3): 152-154.
    [10]STUDY OF PREPARATION ON CONTRACEPTIVE CREAM AND ITS PERCUTANEOUS ABSORPTION[J]. Journal of China Pharmaceutical University, 1987, (4): 247-250.

  • Cited by

    Periodical cited type(4)

    1. 林超，袁于民. PEG的分散性及结构对PEG化胶束在BSA溶液中稳定性的影响. 浙江理工大学学报(自然科学). 2024(06): 743-752 .
    2. 宋璇，秦迎丹，孙晨，刘勃，孙玉琦. 不同Zeta电位纳米脂蛋白载体的物理稳定性评价. 中国医院药学杂志. 2023(12): 1342-1346 .
    3. 周敬，郑宝玉，李阳杰，张国民. 聚乙二醇修饰高良姜素纳米结构脂质载体处方优化及口服药动学评价. 中草药. 2023(14): 4455-4466 .
    4. 王朔，戎媛. 聚乙二醇分子结构研究. 煤炭与化工. 2021(11): 151-156+160 .

    Other cited types(2)

Catalog

    Get Citation
    PDF
    XML
    Article views (186) PDF downloads (627) Cited by(6)
    Turn off MathJax
    Article Contents
    Abstract
    References
    Related Articles

    Copyright © Journal of China Pharmaceutical University苏ICP备12050101号-2

    Address：24 Tongjia Lane, Nanjing City, Jiangsu Province （210009）Tel: 025-83271566E-mail: xuebao@cpu.edu.cn

    Supported by: Beijing Renhe Information Technology Co., Ltd.  Baidu Analytics

    Total visits：292781

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return