Protective effect of<i> Ganoderma lucidum</i> spore glycopeptide on liver injury in mice

FENG Peng; FEI Xuan; CHEN Yan; GUO Qinglong; FANG Weirong

doi:10.11665/j.issn.1000-5048.20210513

Journal of China Pharmaceutical University > 2021 > 52(5): 603-608. > DOI: 10.11665/j.issn.1000-5048.20210513

FENG Peng, FEI Xuan, CHEN Yan, GUO Qinglong, FANG Weirong. Protective effect of Ganoderma lucidum spore glycopeptide on liver injury in mice[J]. Journal of China Pharmaceutical University, 2021, 52(5): 603-608. DOI: 10.11665/j.issn.1000-5048.20210513

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Protective effect of Ganoderma lucidum spore glycopeptide on liver injury in mice

1.
Zhongke Health Industry Co., Ltd., Nanjing 210008
2.
School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, China

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Received Date: January 24, 2021
Revised Date: September 13, 2021

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Abstract

Models of acute and chronic liver injury in mice were established using carbon tetrachloride (CCl₄) and ethanol to explore the protective effects of Ganoderma lucidum spore glycopeptide on liver injury.Different dosage of Ganoderma lucidum spore glycopeptide (65,130,260 mg/kg) were given by gavage.The liver index and the levels of serum aspartate transaminase (AST) and alanine transaminase (ALT) were determined.The contents of liver interleukin-6 (IL-6), tumor necrosis factor (TNF-α) and inducible nitric oxide synthase (iNOS) were tested by enzyme-linked immunosorbent assay (ELISA).The pathological injury of liver tissue was observed by HE staining.The results showed that Ganoderma lucidum spore glycopeptide could significantly reduce the liver index and the contents of serum AST and ALT in mice of acute and chronic liver injury.In mice of chronic liver injury induced by CCl₄, Ganoderma lucidum spore glycopeptide could significantly decrease the contents of liver IL-6, TNF-α and iNOS, and alleviate the pathological damage of liver tissue.Results suggested that Ganoderma lucidum spore glycopeptide might reduce acute and chronic liver injury with anti-inflammatory effects in mice.
- Ganoderma lucidum spore glycopeptide,
- acute liver injury,
- chronic liver injury,
- CCl₄,
- ethanol

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