Application of bioisostere-bicyclo 1.1.1 pentane (BCP) in drug design

HUANG Yu; ZHANG Yinsheng

doi:10.11665/j.issn.1000-5048.20220101

Journal of China Pharmaceutical University > 2022 > 53(1): 1-9. > DOI: 10.11665/j.issn.1000-5048.20220101

HUANG Yu, ZHANG Yinsheng. Application of bioisostere-bicyclo [1.1.1] pentane (BCP) in drug design[J]. Journal of China Pharmaceutical University, 2022, 53(1): 1-9. DOI: 10.11665/j.issn.1000-5048.20220101

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Application of bioisostere-bicyclo [1.1.1] pentane (BCP) in drug design

Jiangsu Key Laboratory of Targeted Antiviral Research, Chia Tai Tianqing Pharmaceutical Group, Nanjing 211100, China

Funds: This study was supported by the Program of Jiangsu Key Laboratory of Targeted Antiviral Research ([2019]No.1627)

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Received Date: June 15, 2021
Revised Date: January 02, 2022

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Abstract

With the development of medicinal and organic chemistry, more and more classical and non-classical bioisosteres are used in the design of novel drugs.Bicyclo[1.1.1] pentane (BCP), as a bioisostere of benzene, t-butyl and alkyne moieties,has recently received extensive attention from medicinal and organic chemists.This paper briefly reviews its application in drug design to provide reference for drug discovery researchers.
- bicyclo[1.1.1] pentane,
- bioisostere,
- drug design

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