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QI Weiyan, XIA Chunlei, AN Roujin, Gao Xinmei, LI Dongping, XU Hanmei. Suppressive effect of lignans from Euphorbia neriifolia L.on esophageal squamous cancer cell[J]. Journal of China Pharmaceutical University, 2022, 53(1): 93-98. DOI: 10.11665/j.issn.1000-5048.20220114
Citation: QI Weiyan, XIA Chunlei, AN Roujin, Gao Xinmei, LI Dongping, XU Hanmei. Suppressive effect of lignans from Euphorbia neriifolia L.on esophageal squamous cancer cell[J]. Journal of China Pharmaceutical University, 2022, 53(1): 93-98. DOI: 10.11665/j.issn.1000-5048.20220114
shu

Suppressive effect of lignans from Euphorbia neriifolia L.on esophageal squamous cancer cell

  • 1.

    The Engineering Research Center of Synthetic Polypeptide Drug Discovery and Evaluation of Jiangsu Province, China Pharmaceutical University, Nanjing 211198

  • 2.

    State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, China

Funds: This study was supported by the Natural Science Foundation of Jiangsu Province (No.BK20180569)
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  • Received Date: May 13, 2021
  • Revised Date: January 05, 2022
    Graphical Abstract
    • Abstract
  • Eubhorbia neriifolia L. is a plant of Euphorbia family.Five known lignans were isolated from the aerial parts of E. neriifolia L. by silica gel for column chromatography and preparative high-performance liquid chromatography (HPLC).Their potential antitumor activities were evaluated in vitro.Compound 2 exhibited proliferation inhibition and cytotoxicity against esophageal squamous cancer cells, especially KYSE-410 and KYSE-450 cells.Further analyses showed that compound 2 could significantly induce apoptosis through the activation of caspase 3/9 and down-regulation of the Bcl-2/Bax protein ratio.These results suggested that compound 2 had a significant inhibitory effect on the esophageal squamous cancer cells, especially KYSE-410, which deserves further research as a potential antitumor agent.
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    • References (17)
  • [1]
    . Phytochemistry，2006，67（18）：1977-1984.
    [2]
    Mali PY，Panchal SS. Euphorbia neriifolia L.：review on botany，ethnomedicinal uses，phytochemistry and biological activities［J］. Asian Pac J Trop Med，2017，10（5）：430-438.
    [3]
    Sharma V，Pracheta. Anti-carcinogenic potential of Euphorbia neriifolia leaves and isolated flavonoid against N-nitrosodiethylamine-induced renal carcinogenesis in mice［J］. Indian J Biochem Biophys，2013，50（6）：521-528.
    [4]
    Shi QW，Su XH，Kiyota H. Chemical and pharmacological research of the plants in genus Euphorbia［J］. Chem Rev，2008，108（10）：4295-4327.
    [5]
    Su BN，Park EJ，Mbwambo ZH，et al. New chemical constituents of Euphorbia quinquecostata and absolute configuration assignment by a convenient Mosher ester procedure carried out in NMR tubes［J］. J Nat Prod，2002，65（9）：1278-1282.
    [6]
    Zhang J，Chen JJ，Liang ZZ，et al. New lignans and their biological activities［J］. Chem Biodivers，2014，11（1）：1-54.
    [7]
    Valcic S，Montenegro G，Timmermann BN. Lignans from Chilean Propolis［J］. J Nat Prod，1998，61（6）：771-775.
    [8]
    Brito-Zeron P，Baldini C，Bootsma H，et al. Sjogren syndrome［J］. Nat Rev Dis Primers，2016，2：16047.
    [9]
    Xu JJ，Tan NH. New lignans from Jatropha curcas linn［J］. Z Naturforsch B，2012，67：176.
    [10]
    Monthong W，Pitchuanchom S，Nuntasaen N，et al. （+）-Syringaresinol lignan from new species Magnolia thailandica［J］. Am J Appl Sci，2011，8（12）：1268-1271.
    [11]
    Liu XM，Rodeheaver DP，White JC，et al. A comparison of in vitro cytotoxicity assays in medical device regulatory studies［J］. Regul Toxicol Pharmacol，2018，97：24-32.
    [12]
    Deng JY，Chen H，Zhou DZ，et al. Comparative genomic analysis of esophageal squamous cell carcinoma between Asian and Caucasian patient populations［J］. Nat Commun，2017，8（1）：1533.
    [13]
    Li YX，Zhang LL，Qu T，et al. Conservation and divergence of mitochondrial apoptosis pathway in the Pacific oyster，Crassostrea gigas［J］. Cell Death Dis，2017，8（7）：e2915.
    [14]
    Wang ZX，Fang JF，Xiao JZ. Correlation of the expression of inflammatory factors with expression of apoptosis-related genes Bax and Bcl-2，in burned rats［J］. Exp Ther Med，2019，17（3）：1790-1796.
    [15]
    Cao L，Zhou YM，Zhai BB，et al. Sphere-forming cell subpopulations with cancer stem cell properties in human hepatoma cell lines［J］. BMC Gastroenterol，2011，11：71.
    [16]
    Dawood S，Austin L，Cristofanilli M. Cancer stem cells：implications for cancer therapy［J］. Oncology （Williston Park），2014，28（12）：1101-1107，1110.
    [17]
    Goodwin Jinesh G，Willis DL，Kamat AM. Bladder cancer stem cells：biological and therapeutic perspectives［J］. Curr Stem Cell Res Ther，2014，9（2）：89-101.
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