Advances in rheological study of topical preparations for skin

LIU Zhihao; HENG Weili; QIAN Shuai; WEI Yuanfeng; ZHANG Jianjun; GAO Yuan

doi:10.11665/j.issn.1000-5048.20220116

Journal of China Pharmaceutical University > 2022 > 53(1): 105-112. > DOI: 10.11665/j.issn.1000-5048.20220116

LIU Zhihao, HENG Weili, QIAN Shuai, WEI Yuanfeng, ZHANG Jianjun, GAO Yuan. Advances in rheological study of topical preparations for skin[J]. Journal of China Pharmaceutical University, 2022, 53(1): 105-112. DOI: 10.11665/j.issn.1000-5048.20220116

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Advances in rheological study of topical preparations for skin

1.
School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198
2.
School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China

Funds: This work was supported by the National Natural Science Foundation of China (No.81873012, No.82074029), the "Double First-Class" Project of China Pharmaceutical University (No.CPU2018GY11, No.CPU2018GY27, No.3342100010, No.2632021ZD15) and China Postdoctoral Science Foundation (No.2021M693517)

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Received Date: January 21, 2021
Revised Date: June 03, 2021

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Abstract

Abstract

Topical preparations for skin, including the commonly used dosage forms of ointments, creams, gels, patches and plasters, are convenient and can avoid the first-pass effect of drugs.Rheological study, which describes the flow characteristics and mechanical properties of products relevant to their Critical Quality Attributes, has become the main focus for topical preparations.Liquid and solid behaviors of products are usually investigated via steady rheology as well as dynamic rheology.This article reviews the research on topical preparations for skin and the data analysis models based on two rheological methods, aiming to provide some references for the rheological evaluation of topical preparations.
- topical preparation for skin,
- steady rheology,
- dynamic rheology,
- data analysis models,
- advances

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References (50)

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