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WANG Wendie, ZHOU Jiyuan, TANG Lidan, YIN Tingjie. Preparation and characterization of dasatinib albumin micelles[J]. Journal of China Pharmaceutical University, 2022, 53(3): 286-292. DOI: 10.11665/j.issn.1000-5048.20220305
Citation: WANG Wendie, ZHOU Jiyuan, TANG Lidan, YIN Tingjie. Preparation and characterization of dasatinib albumin micelles[J]. Journal of China Pharmaceutical University, 2022, 53(3): 286-292. DOI: 10.11665/j.issn.1000-5048.20220305
shu

Preparation and characterization of dasatinib albumin micelles

  • 1.

    Department of Pharmacy, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou 213000

  • 2.

    Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China

Funds: This study was supported by the Second Batch of Municipal Science and Technology Projects of Changzhou (No.CJ20199005) and the National Natural Science Foundation of China (No.81972835)
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  • Received Date: December 21, 2021
  • Revised Date: March 06, 2022
    Graphical Abstract
    • Abstract
  • In this study, a polyethylene glycol and dodecaldehyde modified bovine serum albumin (PEG-DSA) was developed, and its feasibility as a new high-efficiency micellar carrier for dasatinib (DAS) was explored.Circular dichroism, 1H NMR, elemental analysis, FT-IR and other methods were used to characterize the material structure and the single factor method was used to optimize the process of PEG-DSA/DAS micelles and non-PEGylated control micelles DSA/DAS.The results indicated that the optimal formulation was obtained with a mass ratio of 4∶1 between PEG-DSA and DAS, with average particle size of (37.21 ± 0.21) nm, polydispersion index (PDI) of (0.24 ± 0.04), Zeta potential of ? (15.68 ± 0.19) mV, drug loading (DL) capacity of (10.22 ± 0.34) %, and encapsulation efficiency (EE) of (42.73 ± 1.15) %. Compared with the currently reported nano-formulations of DAS, the drug loading of PEG-DSA/DAS micellar formulations was significantly increased with potential for further development.
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    • References (10)
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