• 中国精品科技期刊
  • 中国高校百佳科技期刊
  • 中国中文核心期刊
  • 中国科学引文数据库核心期刊
Advanced Search
WANG Ye, XU Lei, XU Peng, HANG Taijun, SONG Min, WANG Youmei, XU Hui. Optimization and validation of the analytical methods to detect common illicit drugs in sewage[J]. Journal of China Pharmaceutical University, 2022, 53(4): 467-472. DOI: 10.11665/j.issn.1000-5048.20220409
Citation: WANG Ye, XU Lei, XU Peng, HANG Taijun, SONG Min, WANG Youmei, XU Hui. Optimization and validation of the analytical methods to detect common illicit drugs in sewage[J]. Journal of China Pharmaceutical University, 2022, 53(4): 467-472. DOI: 10.11665/j.issn.1000-5048.20220409
shu

Optimization and validation of the analytical methods to detect common illicit drugs in sewage

  • 1.

    School of Pharmacy, China Pharmaceutical University, Nanjing 210009

  • 2.

    Office of China National Narcotics Control Commission China Pharmaceutical University Joint Laboratory on Key Technologies of Narcotics Control, Nanjing 210009

  • 3.

    Drug Control Information and Technology Center of Ministry of Public Security of the People's Republic of China, Beijing 100741, China

More Information
  • Received Date: November 10, 2021
  • Revised Date: June 01, 2022
    Graphical Abstract
    • Abstract
  • The waste water-based epidemiology is an important technique to fight against drug abuse by analyzing the concentration of illicit drugs in urban sewage, which can monitor the abuse of drugs.An SPE-UPLC-MS/MS method was developed for the analysis of 12 common drugs and their metabolites involving amphetamine and morphine.It was shown that the best result was achieved when hydrochloric acid/ acetonitrile (5∶95) was added to acidify the sample during the concentration process, guaranteeing the anti-across contamination of the analysis of organic nitrogen basic trace components, and improve the stability, specificity, and accuracy of the method.The optimized method meets the analytical requirements of complex sewage samples, and has been successfully applied to the assessment of urban drug abuse through sewage analysis.
    • FullText(HTML)
    • References (28)
  • [1]
    . （2021-06-24） https：//www.unodc.org/unodc/en/data-and-analysis/wdr2021.html.
    [2]
    China National Narcotic Control Committee. 2020 Report of Drug Situation of China［EB/OL］. （2021-07-16）. http：//www.nncc626.com/2021-07/16/c_1211244064.htm.
    [3]
    Daughton CG，Jones-Lepp TL. Pharmaceuticals and Care Products in the Environment［M］. Washington，DC： American Chemical Society，2001.
    [4]
    Zuccato E，Chiabrando C，Castiglioni S，et al. Cocaine in surface waters： a new evidence-based tool to monitor community drug abuse［J］. Environ Health，2005，4：14.
    [5]
    Zhou ZG，Zheng LJ，Wang JL. Simultaneous determination of metabolites for three drugs in the wastewater by SPE UPLC-MS/MS［J］. Chin J Pharm Anal（药物分析杂志），2017，37（10）：1876-1881.
    [6]
    Baker DR，Barron L，Kasprzyk-Hordern B. Illicit and pharmaceutical drug consumption estimated via wastewater analysis. Part A：chemical analysis and drug use estimates［J］. Sci Total Environ，2014，487：629-641.
    [7]
    Hou CZ，Hua ZD，Xu P，et al. Research and application progress on evaluation of the abuse of illicit drugs based on wastewater analysis［J］. J China Pharm Univ（中国药科大学学报），2018，49（4）：502-508.
    [8]
    Wang B，Du R，Wang CK，et al. Analysis of drugs in wastewater and its application in forensic drug intelligence［J］. Chin J Forensic Med（中国法医学杂志），2018，33（6）：613-617.
    [9]
    Hou LL，Li SJ，Li XQ，et al. Review on sewage epidemiology of illicit drugs［J］. Environ Sci Technol（环境科学与技术），2017，40（10）：106-110.
    [10]
    van Nuijs ALN，Lai FY，Been F，et al. Multi-year inter-laboratory exercises for the analysis of illicit drugs and metabolites in wastewater：development of a quality control system［J］. Trac Trends Anal Chem，2018，103：34-43.
    [11]
    Ort C，Lawrence MG，Rieckermann J，et al. Sampling for pharmaceuticals and personal care products （PPCPs） and illicit drugs in wastewater systems：are your conclusions valid？A critical review［J］. Environ Sci Technol，2010，44（16）：6024-6035.
    [12]
    McCall AK，Bade R，Kinyua J，et al. Critical review on the stability of illicit drugs in sewers and wastewater samples［J］. Water Res，2016，88：933-947.
    [13]
    Zhang K，Zhou XX，Wang L，et al. Study on distribution characteristics and detection technology of trace drugs in sewage ［J］. Police Technol（警察技术），2017（3）：88-90.
    [14]
    van Nuijs ALN，Castiglioni S，Tarcomnicu I，et al. Illicit drug consumption estimations derived from wastewater analysis：a critical review［J］. Sci Total Environ，2011，409（19）：3564-3577.
    [15]
    Gao TT，Du P，Xu ZQ，et al. Optimization and validation of the analytical method to detect common illicit drugs in wastewater［J］. Environ Sci（环境科学），2017，38（1）：201-211.
    [16]
    Bijlsma L，Sancho JV，Pitarch E，et al. Simultaneous ultra-high-pressure liquid chromatography-tandem mass spectrometry determination of amphetamine and amphetamine-like stimulants，cocaine and its metabolites，and a Cannabis metabolite in surface water and urban wastewater［J］. J Chromatogr A，2009，1216（15）：3078-3089.
    [17]
    Hou LL，Deng DH，Li SJ，et al. Analytical methods for illicit drugs in environmental waters［J］. Environ Chem（环境化学），2017，36（6）：1280-1287.
    [18]
    Castiglioni S，Zuccato E，Crisci E，et al. Identification and measurement of illicit drugs and their metabolites in urban wastewater by liquid chromatography-tandem mass spectrometry［J］. Anal Chem，2006，78（24）：8421-8429.
    [19]
    González-Mari?o I，Quintana JB，Rodríguez I，et al. Comparison of molecularly imprinted，mixed-mode and hydrophilic balance sorbents performance in the solid-phase extraction of amphetamine drugs from wastewater samples for liquid chromatography-tandem mass spectrometry determination［J］. J Chromatogr A，2009，1216（48）：8435-8441.
    [20]
    Wang JY，Hou CZ，Hua ZD，et al. Simultaneous determination of illicit drugs and their metabolites in wastewater by SPE-UPLC-MS/MS［J］. J China Pharm Univ（中国药科大学学报），2020，51（3）：305-312.
    [21]
    Gao JF，O'Brien J，Du P，et al. Measuring selected PPCPs in wastewater to estimate the population in different cities in China［J］. Sci Total Environ，2016，568：164-170.
    [22]
    Kim KY，Oh JE. Evaluation of pharmaceutical abuse and illicit drug use in South Korea by wastewater-based epidemiology［J］. J Hazard Mater，2020，396：122622.
    [23]
    Bishop N，Jones-Lepp T，Margetts M，et al. Wastewater-based epidemiology pilot study to examine drug use in the Western United States［J］. Sci Total Environ，2020，745：140697.
    [24]
    Jones WM. Vapor pressures of tritium oxide and deuterium oxide. Interpretation of the isotope effects［J］. J Chem Phys，1968，48（1）：207-214.
    [25]
    Ding BF，Shao L，Zhang RS，et al. Research progress on abused drugs metabolic in vivo［J］. J Forensic Med（法医学杂志），2016，32（4）：290-295.
    [26]
    Xie P，Wang TJ，Yin G，et al. UPLC-MS/MS determination of metabolites for 10 drugs resided in the hair of drug abusers［J］. Chin J Pharm Anal（药物分析杂志），2014，34（3）：516-522.
    [27]
    Peng SX. Medicinal Chemistry（药物化学）［M］. Beijing：China Medical Science Press，2007，135-135.
    [28]
    Ellefsen KN，da Costa JL，Concheiro M，et al. Cocaine and metabolite concentrations in DBS and venous blood after controlled intravenous cocaine administration［J］. Bioanalysis，2015，7（16）：2041-2056.
    • Related Articles

  • Related Articles

    [1]ZHANG Huili, LU Guangli, HUANG Wenlong, HU Guoqiang. Synthesis and antitumor activity of pefloxacin C-3 methylene rhodanine devatives[J]. Journal of China Pharmaceutical University, 2019, 50(6): 672-677. DOI: 10.11665/j.issn.1000-5048.20190606
    [2]ZHANG Huili, LI Ke, ZHAO Hui, HU Guoqiang, HUANG Wenlong. Synthesis and antitumor activity of fluoroquinolone C-3 s-triazole Schiff-base carboxylic acid derivatives from pefloxacin(X)[J]. Journal of China Pharmaceutical University, 2017, 48(2): 167-171. DOI: 10.11665/j.issn.1000-5048.20170206
    [3]XIE Yusuo, GAO Liuzhou, YAN Qiang, WU Shumin, NI Lili, HUANG Wenlong, ZHAO Hui, HU Guoqiang. Synthesis and antitumor activities of fluoroquinolone C-3 isosteres(VIII):s-triazole sulfide-one thiosemicarbazone derivatives from pefloxacin[J]. Journal of China Pharmaceutical University, 2015, 46(4): 416-420. DOI: 10.11665/j.issn.1000-5048.20150405
    [4]QIAO Yixue, MOU Yi, HUANG Zhangjian, AI Yong, KANG Fenghua, LAI Yisheng, ZHANG Yihua. Synthesis and antitumor activities of novel CDDO-Me analogues[J]. Journal of China Pharmaceutical University, 2015, 46(3): 289-293. DOI: 10.11665/j.issn.1000-5048.20150305
    [5]CHEN Shumin, HUANG Wenlong, HU Guoqiang. Synthesis and antitumor activities of fluoroquinolone C-3 isosteres(VI):s-triazole-acylhydrazone methylsulfide derivatives[J]. Journal of China Pharmaceutical University, 2014, 45(5): 511-516. DOI: 10.11665/j.issn.1000-5048.20140501
    [6]CHEN Shumin, HUANG Wenlong, HU Guoqiang. Synthesis and antitumor activity of fluoroquinolone C-3 isostere V: ciprofloxacin acylhydrazone derivatives[J]. Journal of China Pharmaceutical University, 2014, 45(2): 161-164. DOI: 10.11665/j.issn.1000-5048.20140205
    [7]SUN Yusheng, XU Qiuju, HOU Lili, YUE Xibo, WU Zhaofeng, HUANG Wenlong, XIE Songqiang, HU Guoqiang. Synthesis and antitumor activities of fluoroquinolone C-3 isosteres(IV):s-triazole-oxadiazole methylsulfide Mannich-base derivatives[J]. Journal of China Pharmaceutical University, 2014, 45(1): 39-42. DOI: 10.11665/j.issn.1000-5048.20140106
    [8]HU Kun, ZHOU Anfei, JIANG Hefei, XU Yuanyuan, HUANG Qianhui, YANG Jie, CHEN Xin, REN Jie. Synthesis and antitumor activities of podophyllotoxin derivatives[J]. Journal of China Pharmaceutical University, 2014, 45(1): 33-38. DOI: 10.11665/j.issn.1000-5048.20140105
    [9]XU Qiuju, HOU Lili, WU Xiaokui, XIE Songqiang, HU Guoqiang, HUANG Wenlong. Synthesis and antitumor activity of ciprofloquinolone bis-(C3/C7 hydrazone)s[J]. Journal of China Pharmaceutical University, 2013, 44(1): 35-38. DOI: 10.11665/j.issn.1000-5048.20130105
    [10]HU Guo-qiang, HOU Li-li, WANG Guo-qiang, DUAN Nan-nan, WEN Xiao-yi, CAO Tie-yao, HUANG Wen-long. Synthesis and antitumor and antibacterial activities of fluoroquinolone C-3 isosteres I.norfloxacin C-3 carbonylhydrazone derivatives[J]. Journal of China Pharmaceutical University, 2012, 43(4): 298-301.

Catalog

    Get Citation
    PDF
    XML
    Article views (175) PDF downloads (392) Cited by()
    Turn off MathJax
    Article Contents
    Abstract
    References
    Related Articles

    Copyright © Journal of China Pharmaceutical University苏ICP备12050101号-2

    Address：24 Tongjia Lane, Nanjing City, Jiangsu Province （210009）Tel: 025-83271566E-mail: xuebao@cpu.edu.cn

    Supported by: Beijing Renhe Information Technology Co., Ltd.  Baidu Analytics

    Total visits：297216

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return