Research progress of taste masking and evaluation technology of medicine

FENG Wanting; DENG Yaochen; ZHANG Hui; LI Meng; WANG Zengming; ZHENG Aiping

doi:10.11665/j.issn.1000-5048.20221106002

Journal of China Pharmaceutical University > 2023 > 54(4): 410-420. > DOI: 10.11665/j.issn.1000-5048.20221106002

FENG Wanting, DENG Yaochen, ZHANG Hui, LI Meng, WANG Zengming, ZHENG Aiping. Research progress of taste masking and evaluation technology of medicine[J]. Journal of China Pharmaceutical University, 2023, 54(4): 410-420. DOI: 10.11665/j.issn.1000-5048.20221106002

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Research progress of taste masking and evaluation technology of medicine

1.
School of Pharmacy North China University of Science and Technology, Hebei 063210
2.
Institute of Toxicology and Pharmacology, Academy of Military Medical Sciences, Beijing 100850
3.
School of Pharmacy, Guangdong Medical University；Guangdong 523822, China

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Received Date: November 05, 2022
Revised Date: April 08, 2023

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Abstract

Abstract

Most drugs taste bitter and irritating, resulting in poor compliance of patients, and the bad odor affects the therapeutic effect. The successful research and development of a drug should not only conform to the five quality characteristics of effectiveness, stability, safety, uniformity and economy, but also the compliance of patients to drugs with bad odor. The development of taste masking techniques is critical for bitter drugs.This review describes the principles, advantages and drawbacks of traditional taste masking techniques, and introduces the mechanism and application of novel taste masking techniques, such as melt granulation, hot melt extrusion, 3D printing, drug complex preparation, and bitter taste inhibitors. The in vitro evaluation methods of drug taste masking effect, such as functional magnetic resonance imaging, in vitro dissolution, and electronic tongue technology, are described. And introduce in vivo evaluation methods, such as animal and human taste, in the field of taste masking effect. A new strategy of BP neural network prediction model for drug taste evaluation is proposed, with a view to providing theoretical reference for the future research on drug taste masking.
- bitter taste drugs,
- taste masking technology,
- preparation process,
- 3D printing,
- hot melt extrusion method,
- taste evaluation,
- electronic tongue,
- BP neural network

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References (63)

References

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