Research progress of bio-metal organic frameworks in drug delivery system

YU Jiayu; LIN Zezhi; CAO Wei; ZHANG Jianjun; WEI Yuanfeng; GAO Yuan; QIAN Shuai

doi:10.11665/j.issn.1000-5048.20221111003

Journal of China Pharmaceutical University > 2023 > 54(1): 23-33. > DOI: 10.11665/j.issn.1000-5048.20221111003

YU Jiayu, LIN Zezhi, CAO Wei, ZHANG Jianjun, WEI Yuanfeng, GAO Yuan, QIAN Shuai. Research progress of bio-metal organic frameworks in drug delivery system[J]. Journal of China Pharmaceutical University, 2023, 54(1): 23-33. DOI: 10.11665/j.issn.1000-5048.20221111003

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Research progress of bio-metal organic frameworks in drug delivery system

1.
School of Pharmacy, China Pharmaceutical University, Nanjing 211198
2.
School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China

Funds: This work was supported by the National Natural Science Foundation of China (No.8207141408, No.82204636), the Natural Science Foundation of Jiangsu Province (No.SBK2020042291), and China Postdoctoral Science Foundation (No.2020M671665)

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Received Date: November 10, 2022
Revised Date: February 08, 2023

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Abstract

Abstract

In recent years, bio-metal organic frameworks (Bio-MOFs) synthesized with biocompatible ligands have been widely investigated as a potential drug delivery carrier due to their large specific surface area and porosity, rich host-guest intermolecular interactions, and good biocompatibility.In this review, we summarized the design methods of Bio-MOFs including structural and toxic factors, as well as a variety of drug loading methods including click chemistry, with particular focus on recent research advances in Bio-MOFs for pulmonary drug delivery systems, improving pharmaceutical properties of drugs, sustained and controlled drug release, stimulation response and targeted drug delivery systems.Finally, we summarized the bottlenecks that constrain the development of Bio-MOFs in clinical studies of actual pharmaceutical formulations and their future directions for approved formulations, aiming to provide some theoretical reference for promoting the application of Bio-MOFs in drug delivery systems.
- metal organic frameworks,
- biocompatibility,
- synthesis,
- drug loading,
- drug delivery system

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References (63)

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