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LIU Lin, HU Tingting, WANG Mengling, NIE Yao, ZHANG Weijie, WANG Chen, ZOU Bingjie, SONG Qinxin, ZHOU Guohua. Advance on detection method and application based on bioluminescence of luciferase[J]. Journal of China Pharmaceutical University, 2023, 54(4): 389-398. DOI: 10.11665/j.issn.1000-5048.2023021401
Citation: LIU Lin, HU Tingting, WANG Mengling, NIE Yao, ZHANG Weijie, WANG Chen, ZOU Bingjie, SONG Qinxin, ZHOU Guohua. Advance on detection method and application based on bioluminescence of luciferase[J]. Journal of China Pharmaceutical University, 2023, 54(4): 389-398. DOI: 10.11665/j.issn.1000-5048.2023021401

Advance on detection method and application based on bioluminescence of luciferase

Funds: This study was supported by the National Natural Science Foundation of China (No.82173780); the Open Project Program of MOE Key Laboratory of Drug Quality Control and Pharmacovigilance (No.DQCP20/21MS04); National Innovation and Entrepreneurship Training Program for Undergraduate (No.202210316001Z, No.202210316009Z)
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  • Received Date: February 13, 2023
  • Revised Date: March 15, 2023
  • Bioluminescence is a widespread phenomenon in nature, and luminescent organisms can be found both on land and in the ocean. Among them, luciferase based bioluminescence systems have been widely studied, inspiring the exploration of genetic and epigenetic aspects and the development of a series of related assays for in vivo and in vitro studies. This paper summarizes the recent developments of luciferase based bioluminescence assays in terms of bioluminescence systems, types of luciferases, and the development and application of luciferase bioluminescence assays.
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