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WANG Heng, SUN Hao, LIAO Hong. Reaserch progress of microglial phagocytosis in ischemic stroke[J]. Journal of China Pharmaceutical University, 2023, 54(4): 399-409. DOI: 10.11665/j.issn.1000-5048.2023022106
Citation: WANG Heng, SUN Hao, LIAO Hong. Reaserch progress of microglial phagocytosis in ischemic stroke[J]. Journal of China Pharmaceutical University, 2023, 54(4): 399-409. DOI: 10.11665/j.issn.1000-5048.2023022106
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Reaserch progress of microglial phagocytosis in ischemic stroke

  • New Drug Screening Center, Jiangsu Center for Pharmacodynamics Research and Evaluation, China Pharmaceutical University, Nanjing 210009, China

Funds: This study was supported by the National Natural Science Foundation of China (No.82073831)
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  • Received Date: February 20, 2023
  • Revised Date: May 13, 2023
    Graphical Abstract
    • Abstract
  • Ischemic stroke is a major disease affecting human health, and its pathological mechanism has not been fully elucidated. Microglia are important immune cells in the central nervous system, and participate in the pathological process of ischemic stroke.Following an ischemic stroke, a surge in activated microglia occurs, migrating and congregating within the afflicted regions.These microglia engulf deceased cells or fragments, releasing inflammatory or nutritive factors, thereby participating in the pathogenesis of ischemic stroke.The phagocytosis of microglia plays an important role in cerebral ischemic injury and rehabilitation. This article summarizes the molecular mechanism of microglial phagocytosis and reviews the research progress of microglial phagocytosis in ischemic stroke, and discusses the diversity and complexity of microglial phagocytosis in cerebral ischemic injury and rehabilitation, so as to provide new ideas for the treatment and drug development of ischemic stroke.
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