- 中国精品科技期刊
- 中国高校百佳科技期刊
- 中国中文核心期刊
- 中国科学引文数据库核心期刊
| Citation: |
LIU Lanlan, CAI Qilin, ZHANG Wenyan, et al. Pharmacokinetics and in vitro-in vivo correlation of progesterone suspension injection[J]. J China Pharm Univ, 2024, 55(2): 217 − 223. DOI: 10.11665/j.issn.1000-5048.2023050801
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To investigate the in vitro release, in vivo pharmacokinetics, and the in vitro-in vivo correlation of progesterone suspension injection, self-made progesterone suspension injection was taken as an example. The in vitro release curves of three different particle sizes of progesterone suspension injections were measured using paddle method and dialysis bag method. The in vivo pharmacokinetic characteristics of self-made progesterone suspension injection was studied on SD rats. The plasma concentration of self-made progesterone preparation was detected after intramuscular injection, and correlated with the in vitro release profiles obtained by the dialysis bag method after processing by Wagner-Nelson method. The results showed that when the in vitro release of three different particle sizes of progesterone suspension injections was measured by the paddle method, more than 85% was rapidly released within 20 min, while 85% cumulative release was reached at 40 h, 84 h and 120 h by dialysis bag method, respectively. The release rate obtained by the dialysis bag method was basically consistent with the in vivo release trend, with a correlation coefficient of >0.95, indicating a strong in vivo and in vitro correlation. This study provides some reference for the establishment of the in vitro and in vivo correlation of long-acting suspension injection.
| [1] |
Di Renzo GC, Tosto V, Tsibizova V, et al. Prevention of preterm birth with progesterone[J]. J Clin Med, 2021, 10(19): 4511. doi: 10.3390/jcm10194511
|
| [2] |
Kolatorova L, Vitku J, Suchopar J, et al. Progesterone: a steroid with wide range of effects in physiology as well as human medicine[J]. Int J Mol Sci, 2022, 23(14): 7989. doi: 10.3390/ijms23147989
|
| [3] |
Coombes Z, Plant K, Freire C, et al. Progesterone metabolism by human and rat hepatic and intestinal tissue[J]. Pharmaceutics, 2021, 13(10): 1707. doi: 10.3390/pharmaceutics13101707
|
| [4] |
Bulletti C, Bulletti FM, Sciorio R, et al. Progesterone: the key factor of the beginning of life[J]. Int J Mol Sci, 2022, 23(22): 14138. doi: 10.3390/ijms232214138
|
| [5] |
Wang MD, Xue Y, Leng GY, et al. In vitro-in vivo correlation of goserelin acetate microspheres[J]. Acta Pharm Sin (药学学报), 2019, 54(1): 159-165.
|
| [6] |
Andhariya JV, Jog R, Shen J, et al. Development of level A in vitro-in vivo correlations for peptide loaded PLGA microspheres[J]. J Control Release, 2019, 308: 1-13. doi: 10.1016/j.jconrel.2019.07.013
|
| [7] |
Bao QY, Wang XY, Wan B, et al. Development of in vitro-in vivo correlations for long-acting injectable suspensions[J]. Int J Pharm, 2023, 634: 122642. doi: 10.1016/j.ijpharm.2023.122642
|
| [8] |
Han MR, Xu J, Lin YQ. Approaches of formulation bridging in support of orally administered drug product development[J]. Int J Pharm, 2022, 629: 122380. doi: 10.1016/j.ijpharm.2022.122380
|
| [9] |
Zeng SM, Cai WJ, Zeng SQ, et al. Research progress on preparation and evaluation of injectable nanosuspensions by wet media milling technology[J]. Chin J Pharm (中国医药工业杂志), 2022, 53(9): 1251-1261.
|
| [10] |
Praveen R, Prasad Verma PR, Venkatesan J, et al. In vitro and in vivo evaluation of gastro-retentive carvedilol loaded chitosan beads using Gastroplus™[J]. Int J Biol Macromol, 2017, 102: 642-650.
|
| [11] |
Taha NF, Emam MF, Emara LH. A novel combination of Soluplus®/Poloxamer for meloxicam solid dispersions via hot melt extrusion for rapid onset of action. Part 2: comparative bioavailability and IVIVC[J]. Drug Dev Ind Pharm, 2020, 46(8): 1362-1372. doi: 10.1080/03639045.2020.1791164
|
| [12] |
Wang S, Hua YB, Gao X, et al. Research progress ofin vitro-in vivo correlation of injectable polylactide-polyglycolide microspheres[J]. Acta Pharm Sin (药学学报), 2021, 56(1): 158-168.
|
| [13] |
Agnihotri TG, Alexander A, Agrawal M, et al. In vitro-in vivo correlation in nanocarriers: from protein corona to therapeutic implications[J]. J Control Release, 2023, 354 : 794-809.
|
| [14] |
Wan B, Bao QY, Burgess D. Long-acting PLGA microspheres: advances in excipient and product analysis toward improved product understanding[J]. Adv Drug Deliv Rev, 2023, 198: 114857. doi: 10.1016/j.addr.2023.114857
|
| [15] |
Jiang H, Jiang J, Hu P, et al. Measurement of endogenous uracil and dihydrouracil in plasma and urine of normal subjects by liquid chromatography-tandem mass spectrometry[J]. J Chromatogr B Analyt Technol Biomed Life Sci, 2002, 769(1): 169-176. doi: 10.1016/S1570-0232(02)00009-0
|
| [16] |
National Pharmacopoeia Committee. Chinese pharmacopoeia par four[S]. Being: China Medical Science and Technology Press, 2020: 472-474.
|
| [17] |
Simon A, Amaro MI, Healy AM, et al. Comparative evaluation of rivastigmine permeation from a transdermal system in the Franz cell using synthetic membranes and pig ear skin with in vivo-in vitro correlation[J]. Int J Pharm, 2016, 512(1): 234-241. doi: 10.1016/j.ijpharm.2016.08.052
|
| [18] |
Wang W, Wang B, Lian XY, et al. In vivo-in vitro correlation of sustained-release oral dosage forms[J]. Drug Eval Res (药物评价研究), 2011, 34(5): 380-383.
|
| [19] |
Qin MD, Ye GY, Xin JH, et al. Comparison of in vivo behaviors of intramuscularly long-acting celecoxib nanosuspensions with different particle sizes for the postoperative pain treatment[J]. Int J Pharm, 2023, 636: 122793. doi: 10.1016/j.ijpharm.2023.122793
|
| [20] |
Yao SC, Chen NY, Li MM, et al. Elucidating the particle size effect of andrographolide suspensions on their IVIVC performance in oral absorption[J]. Eur J Pharm Biopharm, 2022, 179: 65-73. doi: 10.1016/j.ejpb.2022.08.012
|
| [21] |
Ho MJ, Jeong MY, Jeong HT, et al. Effect of particle size on in vivo performances of long-acting injectable drug suspension[J]. J Control Release, 2022, 341: 533-547.
|
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