Progress of research on the pharmacological effects and mechanisms of emodin

WU Congyu; ZHOU Yue; SHANGGUAN Luxi; YANG Yani; WANG Jingya; YU Junhe; GONG Shuaishuai; KOU Junping

doi:10.11665/j.issn.1000-5048.2023052501

Journal of China Pharmaceutical University > 2023 > 54(5): 634-643. > DOI: 10.11665/j.issn.1000-5048.2023052501

WU Congyu, ZHOU Yue, SHANGGUAN Luxi, YANG Yani, WANG Jingya, YU Junhe, GONG Shuaishuai, KOU Junping. Progress of research on the pharmacological effects and mechanisms of emodin[J]. Journal of China Pharmaceutical University, 2023, 54(5): 634-643. DOI: 10.11665/j.issn.1000-5048.2023052501

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Progress of research on the pharmacological effects and mechanisms of emodin

Department of Pharmacology of Chinese Materia Medica, School of Traditional Chinese Pharmacy, Jiangsu Key Laboratory of Traditional Chinese Medicine Evaluation and Translational Research, China Pharmaceutical University, Nanjing 211198, China

Funds: This study was supported by the National Innovation and Entrepreneurship Training Program for Undergraduate（No.202310316014Z）

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Received Date: May 24, 2023
Revised Date: October 17, 2023

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Abstract

Abstract

As an active hydroxyanthraquinone ingredient, emodin is abundant in Chinese medicine herbs, such as Rheum palmatum, Polygonum cuspidatum and Polygonum multiflorum.Modern pharmacological studies have shown that emodin has a variety of pharmacological activities including anti-tumor, anti-inflammatory and immunoregulatory, antibacterial and anti-viral effects, myocardial protection, neuroprotection, renal protection, bone protection, antifibrosis and so on, which indicate its high medicinal value and broad application prospects.This article aims to summarize the progress in the pharmacological activity and mechanism of action of emodin published in domestic and international journals over the last 5 years and highlight the potential targets and molecular signaling pathways linked with emodin, so as to provide some clues and references for further development and clinical application of emodin.
- emodin,
- pharmacological activity,
- mechanism,
- signaling pathway,
- clinical application

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References

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