Research progress of microneedle in promoting wound healing

CHEN Yating; WU Yue; DENG Zixian; ZHANG Yunqing; WU Shixun; SHEN Bingzheng

doi:10.11665/j.issn.1000-5048.2023082303

Journal of China Pharmaceutical University > 2024 > 55(4): 557-564. > DOI: 10.11665/j.issn.1000-5048.2023082303

CHEN Yating, WU Yue, DENG Zixian, et al. Research progress of microneedle in promoting wound healing[J]. J China Pharm Univ, 2024, 55(4): 557 − 564. DOI: 10.11665/j.issn.1000-5048.2023082303

Citation:

CHEN Yating, WU Yue, DENG Zixian, et al. Research progress of microneedle in promoting wound healing[J]. J China Pharm Univ, 2024, 55(4): 557 − 564. DOI: 10.11665/j.issn.1000-5048.2023082303

Citation:

CHEN Yating, WU Yue, DENG Zixian, et al. Research progress of microneedle in promoting wound healing[J]. J China Pharm Univ, 2024, 55(4): 557 − 564. DOI: 10.11665/j.issn.1000-5048.2023082303

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Research progress of microneedle in promoting wound healing

CHEN Yating^{1, 2,},
WU Yue^{1, 3},
DENG Zixian²,
ZHANG Yunqing²,
WU Shixun²,
SHEN Bingzheng^{1, 2, 3, ,}

1.
Department of Pharmacy, Renmin Hospital of Wuhan University, Wuhan 430060
2.
The First Clinical School, Wuhan University, Wuhan 430060
3.
Department of Clinical Pharmacy, School of Pharmaceutical Science, Wuhan University, Wuhan 430071, China

Funds: This study was supported by the National Natural Science Foundation of China (No.31700086); Basic Operating Funds of Central Colleges and Universities (2042020GF0030); 2023 National College Students Innovation and Entrepreneurship Training Program (No.202310486103)

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Received Date: August 22, 2023

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Abstract

Abstract

The healing process of skin wounds caused by severe mechanical trauma and chronic diseases (e.g., diabetic foot ulcers) is often accompanied by tissue injury, microbial infection, intense inflammatory reactions, hypertrophic scars, and other complications. Microneedles have been widely used to facilitate wound healing in recent years. According to their different modes of action, microneedle formulation can be categorized into five types: solid microneedles, hollow microneedles, coated microneedles, soluble microneedles, and hydrogel microneedles. This paper reviews the preparation methods and characteristics of microneedles, and summarizes their roles in hemostasis, bacteriostasis, anti-inflammation, enhancement of collagen deposition, and angiogenesis, in the hope of providing some reference for future research and development.
- microneedles,
- drug delivery,
- wound healing,
- antibacterial,
- anti-inflammatory

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References (48)

References

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