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LIU Chang, ZHAO Yongxin, GE Beibei, et al. Research progress on the function of ectopic olfactory receptors and their value as drug targets[J]. J China Pharm Univ, 2024, 55(3): 412 − 419. DOI: 10.11665/j.issn.1000-5048.2023092001
Citation: LIU Chang, ZHAO Yongxin, GE Beibei, et al. Research progress on the function of ectopic olfactory receptors and their value as drug targets[J]. J China Pharm Univ, 2024, 55(3): 412 − 419. DOI: 10.11665/j.issn.1000-5048.2023092001
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Research progress on the function of ectopic olfactory receptors and their value as drug targets

  • Department of Medical Oncology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huaian 223000, China

Funds: This study was supported by the National Natural Science Foundation of China (No. 82103318) and the Natural Science Foundation of Jiangsu Province (No. BK20211112)
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  • Received Date: September 19, 2023
  • Available Online: June 24, 2024
    Graphical Abstract
    • Abstract

  • Olfactory receptors (ORs) are transmembrane proteins mainly distributed in olfactory sensory neurons of the nasal epithelium, mediating the transmission of real-time sensory signals to the brain to produce smell. Recent studies have reported that ORs can also be expressed in tissues or organs outside the nasal cavity, and are closely related to a variety of biological processes, such as sperm chemotaxis, wound healing, glycolipid metabolism and intestinal secretion. In addition, ORs are closely related to a variety of malignant tumors such as prostate cancer, breast cancer and colorectal cancer, and may affect the occurrence and development of tumors by regulating cell proliferation, apoptosis, migration and invasion. This review provides an overview of the effects of ectopic ORs on the function of various human tissues and organs and assesses their potential value as drug targets for the treatment of human diseases.

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