- 中国精品科技期刊
- 中国高校百佳科技期刊
- 中国中文核心期刊
- 中国科学引文数据库核心期刊
| Citation: |
BAI Xishan, DENG Chaorui, LI Yuxiao, et al. Anti-nociceptive effect and mechanism of madecassic acid[J]. J China Pharm Univ, 2024, 55(2): 230 − 235. DOI: 10.11665/j.issn.1000-5048.2023103002
|
To date, the investigation of the functional composition of Centella asiatica (L.) Urban has been mainly focused on the triterpenoid saponins, with little research on the other compositions. The acetic acid-induced writhing, Eddy's hot plate and formalin tests were employed to investigate the anti-nociceptive effects of madecassic acid (MA). The experiment was divided into normal control group, acetylsalicylic acid (ASA) group, and the MA groups of low (10 mg/kg), medium (20 mg/kg) and high (40 mg/kg) dosage. Meanwhile, the anti-nociceptive effect of MA on the acetic acid and formalin-induced nociceptive models in the absence and presence of NAL (naloxone hydrochloride) was evaluated. To have an insight into the anti-nociceptive mechanisms of MA, the capsaicin- and glutamate-induced paw licking tests were also employed to evaluate the involvement of the vanilloid and glutamatergic systems, respectively. Results showed that MA exhibited good anti-nociceptive activity in the acetic acid-induced writhing test and the second phase of formalin test; the anti-nociceptive effect of MA in both the acetic acid and formalin-induced nociception was not effectively removed by NAL; MA (20 mg/kg and 40 mg/kg) effectively reduced the duration of biting/licking the capsaicin-injected paw with inhibition rates of 29.5% and 64.4%, respectively; MA (20 mg/kg and 40 mg/kg) distinctly shortened the time spent in biting/licking the glutamate-injected paw by 30.9% and 56.1%, respectively. In summary, MA induces significant peripheral anti-nociceptive effect, and the anti-nociceptive activities probably involve the modulation of glutamatergic systems and vanilloid systems (TRPV1) instead of the opioidergic system.
| [1] |
Ossipov MH, Morimura K, Porreca F. Descending pain modulation and chronification of pain[J]. Curr Opin Support Palliat Care, 2014, 8(2): 143-151. doi: 10.1097/SPC.0000000000000055
|
| [2] |
Benyamin R, Trescot AM, Datta S, et al. Opioid complications and side effects[J]. Pain Physician, 2008, 11 (2 Suppl): S105-S120.
|
| [3] |
Dumas EO, Pollack GM. Opioid tolerance development: a pharmacokinetic/pharmacodynamic perspective[J]. AAPS J, 2008, 10(4): 537-551. doi: 10.1208/s12248-008-9056-1
|
| [4] |
Savage SR. Long-term opioid therapy: assessment of consequences and risks[J]. J Pain Symptom Manage, 1996, 11(5): 274-286. doi: 10.1016/0885-3924(95)00202-2
|
| [5] |
J]. Chin Wild Plant Res(中国野生植物资源), 2010, 29(3): 6-9.
Yang Y, Ding Y, Xia Y. Advances in the study of analytic methods and pharmacological actions of Centella asiatica L
|
| [6] |
Kraft O, Hartmann AK, Hoenke S, et al. Madecassic acid-a new scaffold for highly cytotoxic agents[J]. Int J Mol Sci, 2022, 23(8): 4362. doi: 10.3390/ijms23084362
|
| [7] |
Hsu YM, Hung YC, Hu LH, et al. Anti-diabetic effects of madecassic acid and rotundic acid[J]. Nutrients, 2015, 7(12): 10065-10075. doi: 10.3390/nu7125512
|
| [8] |
Won JH, Shin JS, Park HJ, et al. Anti-inflammatory effects of madecassic acid via the suppression of NF-kappaB pathway in LPS-induced RAW 264.7 macrophage cells[J]. Planta Med, 2010, 76(3): 251-257. doi: 10.1055/s-0029-1186142
|
| [9] |
Bai XS, Li YH, Li YX, et al. Antinociceptive activity of doliroside B[J]. Pharm Biol, 2023, 61(1): 201-212. doi: 10.1080/13880209.2022.2163407
|
| [10] |
Ayumi RR, Mossadeq WMS, Zakaria ZA, et al. Antinociceptive activity of asiaticoside in mouse models of induced nociception[J]. Planta Med, 2020, 86(8): 548-555. doi: 10.1055/a-1144-3663
|
| [11] |
Wu P. Research progress on the influence of Centella asiatica (L. ) Urban on nervous system[J]. J Med Pharm Chin Minorities (中国民族医药杂志), 2009, 15(11): 71-72.
|
| [12] |
Berkenkopf JW, Weichman BM. Production of prostacyclin in mice following intraperitoneal injection of acetic acid, phenylbenzoquinone and zymosan: its role in the writhing response[J]. Prostaglandins, 1988, 36(5): 693-709. doi: 10.1016/0090-6980(88)90014-7
|
| [13] |
Shibata M, Ohkubo T, Takahashi H, et al. Modified formalin test: characteristic biphasic pain response[J]. Pain, 1989, 38(3): 347-352. doi: 10.1016/0304-3959(89)90222-4
|
| [14] |
Sulaiman MR, Zakaria ZA, Mohamad AS, et al. Antinociceptive and anti-inflammatory effects of the ethanol extract of Alpinia conchigera rhizomes in various animal models[J]. Pharm Biol, 2010, 48(8): 861-868. doi: 10.3109/13880200903302820
|
| [15] |
Jaios ES, Rahman SA, Ching SM, et al. Possible mechanisms of antinociception of methanol extract of Melastoma malabathricum leaves[J]. Rev Bras De Farmacogn, 2016, 26(5): 586-594. doi: 10.1016/j.bjp.2016.01.011
|
| [16] |
Sakurada T, Matsumura T, Moriyama T, et al. Differential effects of intraplantar capsazepine and ruthenium red on capsaicin-induced desensitization in mice[J]. Pharmacol Biochem Behav, 2003, 75(1): 115-121. doi: 10.1016/S0091-3057(03)00066-2
|
| [17] |
Cortright DN, Szallasi A. Biochemical pharmacology of the vanilloid receptor TRPV1. An update[J]. Eur J Biochem, 2004, 271(10): 1814-1819. doi: 10.1111/j.1432-1033.2004.04082.x
|
| [18] |
Caterina MJ, Leffler A, Malmberg AB, et al. Impaired nociception and pain sensation in mice lacking the capsaicin receptor[J]. Science, 2000, 288(5464): 306-313. doi: 10.1126/science.288.5464.306
|
| [19] |
Beirith A, Santos ARS, Calixto JB. Mechanisms underlying the nociception and paw oedema caused by injection of glutamate into the mouse paw[J]. Brain Res, 2002, 924(2): 219-228. doi: 10.1016/S0006-8993(01)03240-1
|
| [20] |
Zhuo M. Ionotropic glutamate receptors contribute to pain transmission and chronic pain[J]. Neuropharmacology, 2017, 112 (Pt A): 228-234.
|
| [1] | ZHANG Zhixing, DENG Hua, TANG Yun. Applications and challenges of artificial intelligence in the development of anticancer peptides[J]. Journal of China Pharmaceutical University, 2024, 55(3): 347-356. DOI: 10.11665/j.issn.1000-5048.2024040201 |
| [2] | HU Zi’ang, GAO Liming, YU Wenying. Advances in the application of artificial intelligence in nucleic acid drug development[J]. Journal of China Pharmaceutical University, 2024, 55(3): 335-346. DOI: 10.11665/j.issn.1000-5048.2024033101 |
| [3] | ZENG Hao, WU Guozhen, ZOU Wuxin, WANG Zhe, SONG Jianfei, SHI Hui, WANG Xiaojian, HOU Tingjun, DENG Yafeng. Optimization of Menin inhibitors based on artificial intelligence-driven molecular factory technology[J]. Journal of China Pharmaceutical University, 2024, 55(3): 326-334. DOI: 10.11665/j.issn.1000-5048.2024040904 |
| [4] | CHEN Baiyu, LYU Lunan, XU Xiaodi, ZHANG Ying, LI Wei, FU Wei. Reflections on improving drug success rates with AIDD and CADD[J]. Journal of China Pharmaceutical University, 2024, 55(3): 284-294. DOI: 10.11665/j.issn.1000-5048.2024011302 |
| [5] | PU Chengtao, GU Lingqian, CHEN Xingye, ZHANG Yanmin. Prediction of human intestinal absorption properties based on artificial intelligence[J]. Journal of China Pharmaceutical University, 2023, 54(3): 355-362. DOI: 10.11665/j.issn.1000-5048.2023032102 |
| [6] | XUE Feng, FENG Shuo, LI Jing. Application and prospect of artificial intelligence in antimicrobial peptides screening[J]. Journal of China Pharmaceutical University, 2023, 54(3): 314-322. DOI: 10.11665/j.issn.1000-5048.2023030901 |
| [7] | GU Zhihao, GUO Wenhao, YAO Hequan, LI Xuanyi, LIN Kejiang. Research progress of the screening and generation of lead compounds based on artificial intelligence model[J]. Journal of China Pharmaceutical University, 2023, 54(3): 294-304. DOI: 10.11665/j.issn.1000-5048.2023042201 |
| [8] | YU Zehao, ZHANG Leiming, ZHANG Mengna, DAI Zhiqi, PENG Chengbin, ZHENG Siming. Artificial intelligence-based drug development: current progress and future challenges[J]. Journal of China Pharmaceutical University, 2023, 54(3): 282-293. DOI: 10.11665/j.issn.1000-5048.2023041003 |
| [9] | WANG Chao, XIAO Fu, LI Miaozhu, PAN Ying, DING Xiao, REN Feng, ZHAVORONKOV Alex, WANG Yazhou. Application progress of artificial intelligence in the screening and identification of drug targets[J]. Journal of China Pharmaceutical University, 2023, 54(3): 269-281. DOI: 10.11665/j.issn.1000-5048.2023041102 |
| [10] | YAN Fangrong. Application and advance of artificial intelligence in biomedical field[J]. Journal of China Pharmaceutical University, 2023, 54(3): 263-268. DOI: 10.11665/j.issn.1000-5048.2023030304 |
Supported by: Beijing Renhe Information Technology Co., Ltd. 
Total visits：292830
DownLoad: