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WANG Lele, QIANG Weijie, WANG Jianjun, et al. Research progress of pharmacological actions and clinical applications of diterpene ginkgolides meglumine injection[J]. J China Pharm Univ, 2024, 55(6): 837 − 844. DOI: 10.11665/j.issn.1000-5048.2023110601
Citation: WANG Lele, QIANG Weijie, WANG Jianjun, et al. Research progress of pharmacological actions and clinical applications of diterpene ginkgolides meglumine injection[J]. J China Pharm Univ, 2024, 55(6): 837 − 844. DOI: 10.11665/j.issn.1000-5048.2023110601
shu

Research progress of pharmacological actions and clinical applications of diterpene ginkgolides meglumine injection

  • 1.

    Department of Pharmacy, Nanjing Drum Tower Hospital, Nanjing 210008

  • 2.

    School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, China

Funds: This study was supported by the National Natural Science Foundation of China (No. 82304986), the Jiangsu Funding Program for Excellent Postdoctoral Talent (2023ZB803), and the China Postdoctoral Science Foundation (2023M741653)
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  • Received Date: November 05, 2023
    Graphical Abstract
    • Abstract

  • Ginkgo biloba L. is a plant belonging to the Ginkgoaceae family and the ginkgo genus, and its roots, leaves and fruits can be used as medicine, with the effects of activating blood and nourishing heart, and tonifying the lung and intestine. Diterpene ginkgolides meglumine injection is based on the ginkgolide, which is the main extract of ginkgo leaf and is a Class V new drug of traditional Chinese medicine. Studies have shown that diterpene ginkgolides meglumine injection has a wide range of pharmacological effects, including anti-oxidation, inhibition of platelet aggregation, improvement of memory, protection of cardiomyocytes and protection of inflammatory damage, etc. It is widely used in clinical treatment of cardiovascular and cerebrovascular diseases, complications of diabetes, and complications of cerebral infarction, etc. Its mechanism of action and targets have also been extensively studied, with a good application prospect. This paper summarizes the clinical application and pharmacological actions of diterpene ginkgolides meglumine injection, in the hope of providing some reference for clinical drug selection and further research and development.

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    • References (62)
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