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CUI Zhenzhen, ZHAO Yifan, SUN Yu, et al. Research progress of drugs for cancer immunotherapy based on CCL2/CCR2 signaling axis[J]. J China Pharm Univ, 2024, 55(1): 36 − 44. DOI: 10.11665/j.issn.1000-5048.2023112904
Citation: CUI Zhenzhen, ZHAO Yifan, SUN Yu, et al. Research progress of drugs for cancer immunotherapy based on CCL2/CCR2 signaling axis[J]. J China Pharm Univ, 2024, 55(1): 36 − 44. DOI: 10.11665/j.issn.1000-5048.2023112904
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Research progress of drugs for cancer immunotherapy based on CCL2/CCR2 signaling axis

  • Jiangsu Provincial Key Laboratory for Functional Substances of Chinese Medicine, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China

Funds: This work was supported by the National Natural Science Foundation of China (No. 82104270) and the Graduate Research and Innovation Projects of Jiangsu Province (KYCX22_2035)
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  • Received Date: November 28, 2023
  • Available Online: March 05, 2024
    Graphical Abstract
    • Abstract

  • C-C motif chemokine ligand 2 (CCL2) and its receptor CCR2 are closely related to tumorigenesis and tumor progression. The CCL2/CCR2 signaling axis promotes tumor progression through multiple mechanisms: CCL2 binds to CCR2 on the surface of tumor cells, and thus promotes tumor growth/survival and metastasis; more importantly, CCL2 recruits a variety of immunosuppressive cells to aggregate in the tumor microenvironment, and inhibits the function and activity of immune cells, promoting tumor progression. The article reviews the CCL2/CCR2 signaling axis and its role in tumors and tumor microenvironment, with particular focus on the advances in clinical research on drugs targeting CCL2/CCR2 signaling axis, in order to gain an in-depth and overall understanding of the mechanism of action of CCL2/CCR2 axis in tumor progression and develop more effective anti-tumor immunotherapeutic agents.

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