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GU Xiao, XING Yingying. Research progress on Helicobacter pylori CagA-induced gastric inflammation-cancer transformation[J]. J China Pharm Univ, 2025, 56(1): 132 − 138. DOI: 10.11665/j.issn.1000-5048.2024022302
Citation: GU Xiao, XING Yingying. Research progress on Helicobacter pylori CagA-induced gastric inflammation-cancer transformation[J]. J China Pharm Univ, 2025, 56(1): 132 − 138. DOI: 10.11665/j.issn.1000-5048.2024022302
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Research progress on Helicobacter pylori CagA-induced gastric inflammation-cancer transformation

  • School of Life Science and Technology, China Pharmaceutical University, Nanjing 211198, China

Funds: This study was supported by the National Natural Science Foundation of China (No. 81971562), and 2024 Hainan Health Science and Technology Innovation Joint Project(WSJK2024MS230)
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  • Received Date: February 22, 2024
    Graphical Abstract
    • Abstract

  • Helicobacter pylori (Hp) is currently classified as a class I carcinogen that can cause gastric cancer, research in recent years on how Hp infection causes the occurrence and progression of gastric cancer has attracted much attention. As the primary virulence factor of Hp, cytotoxicity-associated gene A (CagA) has been extensively studied and reported to function as a key excreted toxin for Hp to induce gastric infection, colonization and promote inflammatory-carcinogenic transformation of host cells. Patients infected with CagA-positive strains have a higher risk of developing tumors compared to those infected with CagA-negative strains. Based on previous studies, this article further elaborates on the import process, biological activity, and related molecular mechanisms of virulence protein CagA in the occurrence and development of gastric cancer induced by Hp infection.

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