Advances in the application of artificial intelligence in nucleic acid drug development

HU Zi’ang; GAO Liming; YU Wenying

doi:10.11665/j.issn.1000-5048.2024033101

Journal of China Pharmaceutical University > 2024 > 55(3): 335-346. > DOI: 10.11665/j.issn.1000-5048.2024033101

HU Zi’ang, GAO Liming, YU Wenying. Advances in the application of artificial intelligence in nucleic acid drug development[J]. J China Pharm Univ, 2024, 55(3): 335 − 346. DOI: 10.11665/j.issn.1000-5048.2024033101

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Advances in the application of artificial intelligence in nucleic acid drug development

1.
Mudi Meng Honors College, China Pharmaceutical University, Nanjing 211198
2.
School of Science, China Pharmaceutical University, Nanjing 211198
3.
School of Life Science and Technology, China Pharmaceutical University, Nanjing 211198, China

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Received Date: March 30, 2024
Available Online: June 24, 2024

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Abstract

In recent years, the field of nucleic acid therapeutics has been flourishing, progressively establishing itself as the third generation of drug modalities following small molecules and antibody-based drugs. Artificial intelligence technology based on machine learning is advancing rapidly, which can significantly accelerate the development process of nucleic acid therapeutics. This review provides an overview of the foundational aspects of artificial intelligence algorithms, databases, and characterizations in the field of nucleic acid drug development. It elucidates the advances in the application of artificial intelligence in nucleic acid structural prediction, small nucleic acid drug design, and other research and development phases of nucleic acid therapeutics, aiming to offer some reference for the interdisciplinary development of artificial intelligence and nucleic acid drugs.

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References

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