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LI Min, MI Yahui, KUAI Haimin, et al. Chemical constituents from the stems of Fritillaria unibracteata[J]. J China Pharm Univ, 2025, 56(2): 160 − 165. DOI: 10.11665/j.issn.1000-5048.2024040302
Citation: LI Min, MI Yahui, KUAI Haimin, et al. Chemical constituents from the stems of Fritillaria unibracteata[J]. J China Pharm Univ, 2025, 56(2): 160 − 165. DOI: 10.11665/j.issn.1000-5048.2024040302

Chemical constituents from the stems of Fritillaria unibracteata

Funds: This study was supported by the Major Science and Technology Special Projects of Yunnan Province (202402AA310001);the Expert Workstation Project of Yunnan Province (202305AF150096); Diqing State-China Pharmaceutical University State-School Cooperation Project (2021ZXYD01)
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  • Received Date: April 02, 2024
  • Chemical investigation of the stems of Fritillaria unibracteata P.K. Hsiao & K.C. Hsia resulted in the isolation of nine compounds, by means of silica gel column chromatography, and preparative HPLC. Based on spectroscopic and chemical evidence, these compounds were identified as: 27-hydroxychlorogenone (1), sieboldogenin (2), (3β, 25S)-spirost-5-ene-3,17,27-triol (3), laxogenin (4), tigogenone (5), cerevisterol (6), ergosterol peroxide (7), stigmaterol (8), and β-sitosterol (9). Compound 1 was a new compound, and compounds 2-9 were isolated from the stems of Fritillaria unibracteata for the first time. The inhibitory effects of compounds 1−9 on A549 cells were determined using the MTT method. The results show that compound 6 exhibits moderate inhibitory activity with an IC50 value of (14.16 ± 1.11) μmol/L.

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