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SHUAI Yubing, WANG Qiudan, HE Tianyu, et al. Mitofusin 2: an emerging drug target[J]. J China Pharm Univ, 2025, 56(1): 1 − 9. DOI: 10.11665/j.issn.1000-5048.2024041001
Citation: SHUAI Yubing, WANG Qiudan, HE Tianyu, et al. Mitofusin 2: an emerging drug target[J]. J China Pharm Univ, 2025, 56(1): 1 − 9. DOI: 10.11665/j.issn.1000-5048.2024041001
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Mitofusin 2: an emerging drug target

  • State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, China

Funds: This study was supported by the National Natural Science Foundation of China (No.82373886)
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  • Received Date: April 09, 2024
  • Revised Date: May 20, 2024
  • Accepted Date: May 21, 2024
    Graphical Abstract
    • Abstract

  • Mitofusin 2 (MFN2) residing on the outer mitochondrial membrane is a pivotal factor participating in mitochondrial fusion and maintaining mitochondrial morphology. Due to its multifaceted cellular functions, MFN2 is implicated in the pathogenesis of diverse maladies, notably type 2 Charcot-Marie-Tooth disease, which has catalyzed a surge in pharmaceutical endeavors directed towards MFN2. This article reviews the function of MFN2 and its role in a variety of diseases, outlines the current status of drug discovery against MFN2, and summarizes potential drug molecules currently in preclinical research, aiming to provide some reference for the research and development of drugs and therapies targeting MFN2.

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    • References (64)
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