- 中国精品科技期刊
- 中国高校百佳科技期刊
- 中国中文核心期刊
- 中国科学引文数据库核心期刊
| Citation: |
CAO Yanfang, WANG Yali, WANG Anhui, et al. Analysis of xenobiotics in colon and immune tissues of ulcerative colitis mice after administration of Sini San by LC-MS[J]. J China Pharm Univ, 2025, 56(1): 73 − 79. DOI: 10.11665/j.issn.1000-5048.2024050801
|
Dysregulation of immune response is currently recognized as one of the important pathological factors in ulcerative colitis (UC). Based on the confirmation that the Sini San (SNS) can significantly improve the colon inflammation induced by dextran sulfate sodium sulfate (DSS) in mice, the present work systematically studied the xenobiotics in the colon and mesenteric lymph nodes, spleen, and thymus of UC mice after administration of SNS by high-performance liquid chromatography-ion trap time-of-flight mass spectrometry (HPLC-IT-TOF-MS). The results showed that, in addition to the colon, some components and their metabolites in SNS could be distributed in immune tissues, and it was found that the quality of relatively low-abundance and weakly responsive components such as saikosaponin a, paeoniflorin, and glycyrrhizic acid had the characteristics of efficient transmission to the colon and lymphoid organs. These components were very likely to be the source of pharmacodynamic substances of SNS. The findings of this study lay a foundation for the study of the efficacy and molecular mechanism of the components against ulcerative colitis, and also provide a scientific basis for the rational clinical application of SNS, which is expected to promote the secondary development of its preparations.
| [1] |
Pan Z, Lin H, Fu Y. Identification of gene signatures associated with ulcerative colitis and the association with immune infiltrates in colon cancer[J]. Front Immunol, 2023, 14: 1086898. doi: 10.3389/fimmu.2023.1086898.
|
| [2] |
Zhang SS, Zhao LQ, Shen H, et al. International clinical practice guideline on the use of traditional Chinese medicine for ulcerative colitis by Board of Specialty Committee of Digestive System Disease of World Federation of Chinese Medicine Societies (2023)[J]. Phytother Res, 2024, 38(2): 970-999. doi: 10.1002/ptr.8087
|
| [3] |
Sun Y, Cai TT, Shen Y, et al. Si-Ni-San, a traditional Chinese prescription, and its active ingredient glycyrrhizin ameliorate experimental colitis through regulating cytokine balance[J]. Int Immunopharmacol, 2009, 9(12): 1437-1443. doi: 10.1016/j.intimp.2009.08.017
|
| [4] |
Cai YJ, Xu B, Zhou F, et al. Si-Ni-San ameliorates chronic colitis by modulating type I interferons-mediated inflammation[J]. Phytomedicine, 2021, 84: 153495. doi: 10.1016/j.phymed.2021.153495
|
| [5] |
Cai YJ, Li X, Han Q, et al. Si-Ni-San improves experimental colitis by favoring Akkermensia colonization[J]. J Ethnopharmacol, 2023, 305: 116067. doi: 10.1016/j.jep.2022.116067
|
| [6] |
Mizuno Y, Shimabukuro K, Kurita K, et al. Thymus abnormalities in ulcerative colitis- comparative study with other autoimmune diseases[J]. Gastroenterol Jpn, 1976, 11(3): 208-214.
|
| [7] |
Chen JX, Duan MB, Zhao YQ, et al. Saikosaponin A inhibits influenza A virus replication and lung immunopathology[J]. Oncotarget, 2015, 6(40): 42541-42556. doi: 10.18632/oncotarget.6448
|
| [8] |
Zhang ZH, Zhang Y, Zhao ZF, et al. Paeoniflorin drives the immunomodulatory effects of mesenchymal stem cells by regulating Th1/Th2 cytokines in oral lichen planus[J]. Sci Rep, 2022, 12(1): 18678. doi: 10.1038/s41598-022-23158-0
|
| [9] |
Zhu SH, Liu BQ, Hao MJ, et al. Paeoniflorin suppressed high glucose-induced retinal microglia MMP-9 expression and inflammatory response via inhibition of TLR4/NF-κB pathway through upregulation of SOCS3 in diabetic retinopathy[J]. Inflammation, 2017, 40(5): 1475-1486. doi: 10.1007/s10753-017-0571-z
|
| [10] |
Richard SA. Exploring the pivotal immunomodulatory and anti-inflammatory potentials of glycyrrhizic and glycyrrhetinic acids[J]. Mediators Inflamm, 2021, 2021: 6699560.
|
| [11] |
Li YR, Chen DY, Chu CL, et al. Naringenin inhibits dendritic cell maturation and has therapeutic effects in a murine model of collagen-induced arthritis[J]. J Nutr Biochem, 2015, 26(12): 1467-1478. doi: 10.1016/j.jnutbio.2015.07.016
|
| [12] |
Wang L, Zhou GB, Liu P, et al. Dissection of mechanisms of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia[J]. Proc Natl Acad Sci U S A, 2008, 105(12): 4826-4831. doi: 10.1073/pnas.0712365105
|
| [1] | ZHANG Xinggui, FANG Siyang, CHEN Rui, XIONG Yile, DONG Huilin, ZHANG Jian, QIN Yanhua, YIN Zhiqi. Volatile aromatic components and pyrolytic products in ethanol extracts of Cyclocarya paliurus by GC-MS[J]. Journal of China Pharmaceutical University, 2024, 55(4): 493-503. DOI: 10.11665/j.issn.1000-5048.2023121501 |
| [2] | XING Xuyang, WANG Xiaochun, HE Wei. Advances in research on tumor immunotherapy and its drug development[J]. Journal of China Pharmaceutical University, 2021, 52(1): 10-19. DOI: 10.11665/j.issn.1000-5048.20210102 |
| [3] | CHEN Yingying, LI Ruiyan, CHEN Huan, ZHANG Yubin. Development and application of drugs targeting the innate and adaptive immune system in the colon[J]. Journal of China Pharmaceutical University, 2016, 47(4): 388-396. DOI: 10.11665/j.issn.1000-5048.20160402 |
| [4] | WANG Xiarong, WANG Yi, CHENG Yiyu, GAO Jianqing. Topical administration of traditional Chinese medicine and the methods for the promotion of drug penetration[J]. Journal of China Pharmaceutical University, 2016, 47(3): 368-376. DOI: 10.11665/j.issn.1000-5048.20160321 |
| [5] | LYU Guangyun, WANG Shuangshuang, HANG Taijun, SONG Min. Qualitative and quantitative analysis of components of Radix Polygalae in herbal pair of Radix Polygalae and Rhizoma Acori Tatarinowii[J]. Journal of China Pharmaceutical University, 2016, 47(3): 329-336. DOI: 10.11665/j.issn.1000-5048.20160314 |
| [6] | SHEN Kai, KOU Junping, YU Boyang. Research advances in the mechanisms of active components in Chinese materia medica against oxidative stress-induced neuronal apoptosis[J]. Journal of China Pharmaceutical University, 2015, 46(5): 532-540. DOI: 10.11665/j.issn.1000-5048.20150503 |
| [7] | HE Wei, QI Haixia, DONG Lei, ZHANG Junfeng. Research advances in drug delivery system targeting immune system[J]. Journal of China Pharmaceutical University, 2015, 46(5): 513-520. DOI: 10.11665/j.issn.1000-5048.20150501 |
| [8] | SHI Song, HUANG Zhen, LUO Yi, CHEN Jiang-ning, ZHANG Jun-feng. Bletilla striata polysaccharide for the treatment of ulcerative colitis in mice[J]. Journal of China Pharmaceutical University, 2012, 43(6): 535-540. |
| [9] | YU Xiao-hua, LIU Xiao-hua, ZHAO Hao-ru, LI Qing-xia, YU Peng. Study of Chang′anning capsules in ulcerative colitis rat model[J]. Journal of China Pharmaceutical University, 2010, 41(6): 563-567. |
| [10] | Establishment of Colon-specific Release Medium of Calcium Pectinate[J]. Journal of China Pharmaceutical University, 2002, (3): 37-41. |
Supported by: Beijing Renhe Information Technology Co., Ltd. 
Total visits：299203
DownLoad: