Research progress on active mechanism and structure feature of polysaccharides from <i>Zizyphus jujube</i> in Rhamnaceae plants

DONG Xiaoqiang; WEN Chang; XU Jindan; SHI Lexue; HU Yulong; LI Jieming; DONG Chunhong; DING Kan

doi:10.11665/j.issn.1000-5048.2024051301

Journal of China Pharmaceutical University > 2024 > 55(4): 443-453. > DOI: 10.11665/j.issn.1000-5048.2024051301

DONG Xiaoqiang, WEN Chang, XU Jindan, et al. Research progress on active mechanism and structure feature of polysaccharides from Zizyphus jujube in Rhamnaceae plants[J]. J China Pharm Univ, 2024, 55(4): 443 − 453. DOI: 10.11665/j.issn.1000-5048.2024051301

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Research progress on active mechanism and structure feature of polysaccharides from Zizyphus jujube in Rhamnaceae plants

DONG Xiaoqiang^{1, 2, 3, 4,},
WEN Chang⁴,
XU Jindan^{2, 3},
SHI Lexue⁴,
HU Yulong^{1, 2, 3},
LI Jieming^{1, 2, 3},
DONG Chunhong^{1, 2, 3, ,},
DING Kan^{1, 2, 3, 4, ,}

1.
Academy of Chinese Medical Science, Henan University of Chinese Medicine, Zhengzhou 450046
2.
Henan Polysaccharide Research Center, Zhengzhou 450046
3.
Henan Key Laboratory of Chinese Medicine for Polysaccharides and Drugs Research, Zhengzhou 450046
4.
Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica,China, Chinese Academy of Sciences, SSIP Healthcare and Medicine Demonstration Zone, Zhongshan Tsuihang New District, Zhongshan 528400, China

Funds: This study was supported by the Natural Science Foundation of Henan Province (No.232300421374); and China Postdoctoral Science Foundation (No.2021M690936)

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Received Date: May 12, 2024

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Abstract

Abstract

The genus jujube (Ziziphus jujuba Mill.) within the Rhamnaceae family encompasses numerous varieties, such as Ziziphus jujuba Mill. var. jujuba, Ziziphus jujuba var. inermis, and var. spinosa, etc. Among these, the jujube fructus has the most abundant cultivated variants across the country, including Ziziphus jujuba cv. Hamidazao and Ziziphus jujuba cv. Huanghetanzao. Jujube plants are rich in variety and are used for both medicinal and food purposes. Polysaccharides, one of the main active ingredients of jujube, are important medicinal components that contribute to its efficacy. Jujube polysaccharides have been found to promote hematopoiesis, exhibit antioxidant and anti-tumor activities, repair liver damage, regulate the immune system, and provide anti-inflammatory effects. By comprehensively summarizing and analyzing the literature on jujube polysaccharides from different varieties and origins, this paper reviews the potential mechanisms of action of jujube polysaccharides in exerting biological activities. It also summarizes the primary structural features, such as relative molecular mass, monosaccharide composition, glycosidic linkage, and the substituent modifications of jujube polysaccharides by sulfation, phosphorylation, carboxymethylation, selenization, and acetylation. This review aims to provide a reference for the research and development of jujube in the fields of innovative polysaccharide drugs and functional foods.
- jujube polysaccharide,
- bioactive mechanism,
- structural analysis,
- structural modification

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