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Zhang Yihua, Zhu Chongquan, Yang Zhenxiang, Cao Guankun, Peng Sixun. Studies On the Non-Steroidal Antifertility Agents Ⅰ. Synthesis of p-Coumaric Acid and Its Analogues[J]. Journal of China Pharmaceutical University, 1981, (1): 63-65.
Citation: Zhang Yihua, Zhu Chongquan, Yang Zhenxiang, Cao Guankun, Peng Sixun. Studies On the Non-Steroidal Antifertility Agents Ⅰ. Synthesis of p-Coumaric Acid and Its Analogues[J]. Journal of China Pharmaceutical University, 1981, (1): 63-65.
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Studies On the Non-Steroidal Antifertility Agents Ⅰ. Synthesis of p-Coumaric Acid and Its Analogues

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  • It was reported that p-coumaric acid showed 100% interceptive activity on day 6 preganant mice at the single oral dose of 50mg/kg of body weight. Thus p-coumaricacid and its eight analogues were synthesized for evaluation of their antifertilityefficacy. Preliminary pharmacological test indicated that p-coumaric acid and compoundⅢ、Ⅷ did not exhibit any antifertility activity in mice.
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