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Zhou Huishu, Huang Cifu, Duan Tinghan. Study of Conversion of Penicillin G Into Cefazolin by Ring Enlargement[J]. Journal of China Pharmaceutical University, 1982, (1): 55-56.
Citation: Zhou Huishu, Huang Cifu, Duan Tinghan. Study of Conversion of Penicillin G Into Cefazolin by Ring Enlargement[J]. Journal of China Pharmaceutical University, 1982, (1): 55-56.
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Study of Conversion of Penicillin G Into Cefazolin by Ring Enlargement

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  • 3-Bromomethylcephembenzhydry1ester S-oxide has been synthesized. It is a general and key intermediate in the preparation of 3-substituted cephalosporins, Using this intermediate, cefazolin has been prepared with a total yield of 5-5.5%.
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