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Xu Fang, Liao Jiangqing, Xie Jinrong. The Utilization of Tigogenin Ⅱ.Synthesis of Auluton -- An Antiarrhythmic Agent[J]. Journal of China Pharmaceutical University, 1982, (2): 83-87.
Citation: Xu Fang, Liao Jiangqing, Xie Jinrong. The Utilization of Tigogenin Ⅱ.Synthesis of Auluton -- An Antiarrhythmic Agent[J]. Journal of China Pharmaceutical University, 1982, (2): 83-87.

The Utilization of Tigogenin Ⅱ.Synthesis of Auluton -- An Antiarrhythmic Agent

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  • This paper describes a method of synthesis of a new anti-arrhythmie agent-Au1uton( V Ⅱ.3α-amin-2β-hydroxy-5α-androstan-17-one hvdrochloride ), prepared fromepiandrosterone (an intermediate - derived from tigogenin) by a six-step process. Some reaction conditions have been modified.When Auluton is made from the azido compound(VI) by pd/c catalytic hydrogenation.a by-product (IX mp 199-201℃) has been obtained. Its structure is identified to be 3α-ch1oro-2β-hydorxy-5α-androstan-17-one by chemical and spectral data.
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