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Synthesis and Inhibitor Activity to Phosphodiesterase of Thieno [3, 4-d] Pyrimidine-2,4-Dione Derivatives[J]. Journal of China Pharmaceutical University, 1991, (3): 142-144.
Citation: Synthesis and Inhibitor Activity to Phosphodiesterase of Thieno [3, 4-d] Pyrimidine-2,4-Dione Derivatives[J]. Journal of China Pharmaceutical University, 1991, (3): 142-144.
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Synthesis and Inhibitor Activity to Phosphodiesterase of Thieno [3, 4-d] Pyrimidine-2,4-Dione Derivatives

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  • In search of novel phosphodiesterase (PDE) inhibitors, twelve compounds of thieno [3,4-d] pyrimidiine-2,4-diones (V a-1) were designed and synthesized with cyanoacetic aicd and urethan taken as the starting materials. Condensation and cyclization were inv
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