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Xu Jiyang, Wu Wutong, Jin Shenghao, Yao Wenbin. Chemico-Enzymatic Synthesis of Sweetener Aspartame[J]. Journal of China Pharmaceutical University, 1994, (1).
Citation: Xu Jiyang, Wu Wutong, Jin Shenghao, Yao Wenbin. Chemico-Enzymatic Synthesis of Sweetener Aspartame[J]. Journal of China Pharmaceutical University, 1994, (1).

Chemico-Enzymatic Synthesis of Sweetener Aspartame

  • This paper deals with the chemico-enzymatic synthesis of sweetener aspartame. N-Maleylphenylalanine methyl ester was prepared by treating maleic anhydrid with L-phenylalanine methyl ester and isomerized to N-fumarylphenylalanine methyl ester (FPM),yield 9
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