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Effects of Guanfu Base G on the Action Potential in Hypoxic, Hyperkalemic and Acidosic Guinea Pig Papllary and Rabbit Sinoatrial Node[J]. Journal of China Pharmaceutical University, 1997, (1): 39-41.
Citation: Effects of Guanfu Base G on the Action Potential in Hypoxic, Hyperkalemic and Acidosic Guinea Pig Papllary and Rabbit Sinoatrial Node[J]. Journal of China Pharmaceutical University, 1997, (1): 39-41.
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Effects of Guanfu Base G on the Action Potential in Hypoxic, Hyperkalemic and Acidosic Guinea Pig Papllary and Rabbit Sinoatrial Node

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  • In the hypoxic, hyperkalemic and acidosic guinea pig papillary muscles, guanfu base G(GFG) 0.86μmol/L further decreased the maximal rate of depolarization(Vmax) , shortened action potential duration(APD) and effective refractory period(ERP) , and had a significant increase in ERP/APD90 ratio. When the sinoatrial nodes were exposed to GFG, their Vmax , rate of diastolic depolarization, spontaneous firing frequency and mean rate of repolarization were decreased, diastolic interval and APD were prolonged. Furthermore, these effects appear to be concentration-dependent.
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