Synthesis of Anti-arrhythymic Sotalol

Journal of China Pharmaceutical University > 1997 > (3): 4-6.

Synthesis of Anti-arrhythymic Sotalol[J]. Journal of China Pharmaceutical University, 1997, (3): 4-6.

Citation:

Synthesis of Anti-arrhythymic Sotalol[J]. Journal of China Pharmaceutical University, 1997, (3): 4-6.

Citation:

Synthesis of Anti-arrhythymic Sotalol[J]. Journal of China Pharmaceutical University, 1997, (3): 4-6.

Abstract

Starting from aniline, and undergoing mesylation, Friedel-Crafts acylation, isopropylami-nation and hydrogenation, sotalol hydrochloride was synthesized. The yields of every step were promoted by modifying the reacting conditions. The total yield reaches

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