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XU Xin, WANG Wei-Dong, ZHANG Yi-Hua, PENG Si-Xun, YANG Qun. ImprovedSynthesis of 3,4-Bis(phenylsulfonyl)-1,2,5-Oxadizole-2-Oxide[J]. Journal of China Pharmaceutical University, 2002, (6).
Citation: XU Xin, WANG Wei-Dong, ZHANG Yi-Hua, PENG Si-Xun, YANG Qun. ImprovedSynthesis of 3,4-Bis(phenylsulfonyl)-1,2,5-Oxadizole-2-Oxide[J]. Journal of China Pharmaceutical University, 2002, (6).
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ImprovedSynthesis of 3,4-Bis(phenylsulfonyl)-1,2,5-Oxadizole-2-Oxide

  • Center of Drug Research,China Pharmaceutical University,Nanjing 210009,China

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  • bis(phenylsulfonyl)-1,2,5-oxadiazole-2-oxide,the NO donor,was synthesized by etherealization of thiophenol,oxidation,and then cyclization with an overall yield of 70%. This process is simpler and the yield of product is higher than that previously reporte
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