Optimization of ambroxol hydrochloride sustained-release tablets formulation by central composite design-response surface methodology

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Journal of China Pharmaceutical University > 2007 > 38(1): 77-79.

Optimization of ambroxol hydrochloride sustained-release tablets formulation by central composite design-response surface methodology[J]. Journal of China Pharmaceutical University, 2007, 38(1): 77-79.

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Optimization of ambroxol hydrochloride sustained-release tablets formulation by central composite design-response surface methodology

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Aim:To optimize the formulation of ambroxol hydrochloride sustained-release tablets by the central composite design-response surface methodology(RSM plus CCD).Methods:In the formulation design using RSM plus CCD,independent variables were the amounts of H
- ambroxol hydrochloride,
- central composite design,
- response surface methodology,
- sustained release tablets,
- overlay contour plot

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Optimization of ambroxol hydrochloride sustained-release tablets formulation by central composite design-response surface methodology

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